Recent Developments of Organocatalysis and their Applications to Process Chemistry

Abstract

Recent developments of organocatalysis and their applications to process chemistry have been described. Especially, three kinds of organocatalysts, a proline catalyst, the diarylprolinol silyl ether catalysts developed by Jørgensen’s group and Hayashi’s group independently (Jørgensen-Hayashi catalysts), and the bifunctional thiourea catalysts developed by Takemoto’s group have been taken up here and discussed. Our applications to the practical synthesis of the intermediate of (S)-Oxybutynin, the intermediate of anti-AIDS drug BFOL, and (R)-Baclofen were also introduced in this review.