Dynamic Kinetic Asymmetric Transformations of Axially Chiral Biaryls with Transition-metal Catalysts

Abstract

Axially chiral biaryl units are key components of natural products and biologically active compounds as well as chiral molecular catalysts, and thus significant efforts have been focused on the efficient synthesis of atropisomerically enriched axially chiral biaryls. Among a variety of strategies, dynamic kinetic resolution is considered as an efficient method in asymmetric synthesis since highly enantio-enriched products could be furnished in quantitative yields from racemic starting materials in the best case. This review highlights recent progress of dynamic kinetic asymmetric transformations of racemic axially chiral biaryls by using transition-metal catalysts.