2017 年 75 巻 6 号 p. 673-674
Oxocarbenium ions are key intermediates in a wide variety of important synthetic transformations. Since they have generally high reactivities and lack of basic sites suitable for interaction with chiral Lewis acids or hydrogen-bond donors, the development of catalytic enantioselective reactions involving oxocarbenium intermediates is a great challenge for chemical synthesis. This review highlights recent progress in developing catalytic enantioselective oxa-Pictet-Spengler reaction.