Abstract
Reaction of N-(1-chloroethyl) phthalimidej and thioglycolic acid at room temperature caused dehydrochlorination and gave N-(1-carboxymethylmercaptoethy1) phthalimide with good yield. This substance can be esterified easily with alcohols in the presence of sulfuric acid as a catalyst.
An addition reaction of thioglycolic acid to N-vinylphthalimide in the presence of sulfuric acid catalyst was followed by Markownikoff's rule and formed an α-addition product, N-(1-carboxymethylmercaptoethyl) phthalimide. Similarly, methyl and ethyl thioglycolate gave additive products.
