Abstract
N-Substituted guanamines have been synthesized from substituted biguanides and carboxylic acid chlorides or esters.
In the present study, it has been found that carboxylic acids and their esters, amides, and nitriles react with biguanides or their hydrochlorides to yield guanamines in good yields when polyphosphoric acid is used as a solvent.
Some new guanamines were thus synthesized from C2-C16 aliphatic carboxylic acids and phenylbiguanide. Some of their physical properties were also reported.
