2-7フェニル-5-オキサゾロンとヨウ化メチルおよびアリル型ハロゲン化合物との反応

「α,α-ジ置換アミノ酸の合成および反応に関する研究」 (第2報)

抄録

The reaction of methyl iodide and allyl-type halides with 2-phenyl-5-oxazolone was carried out in dimethylformamide by use of 50% aqueous solution of potassium hydroxide or triethylamine as a base. When triethylamine was used, better yield was obtained. From methyl iodide, α-benzamino-isobutyric acid was obtained in 49% yield. From allyl halides, disubstituted derivatives (α-benzamino-α, α-diallylacetic acid) were obtained in good yields. Disubstituted derivatives were obtained in good yields (67% or 59%) by the reaction of crotyl bromide or cinnamyl bromide.