有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
Trichothecane型セスキテルペンおよびVerrucarin類の合成
通 元夫
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ジャーナル フリー

1981 年 39 巻 7 号 p. 642-653

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This review deals with the synthetic studies on trichothecane-type sesquiterpenes and verrucarins. Although more than forty compounds were isolated from natural sources, only a few examples of total synthesis of natural products in this class have been reported. They are trichodermin, trichodermol, 12, 13-epoxytrichothec-9-ene, and trichodiene. The total synthesis of an important sesquiterpene, verrucarol, having tow hydroxyl groups at C-4 and C-15 positions, has not yet succeeded. However, some synthetic studies towards the total synthesis of verrucarol are discussed. In the last part, partial syntheses of macrocyclic derivatives of verrucarol, tetrahydroverrucarin J and 2'-deoxy-3'-hydroxytetrahydroverrucarin A, are described.

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