抄録
Nonenzymatic synthesis of oligonucleotides by model reactions of nucleic acid biosynthesis is reviewed. The nucleic acid biosyntheis catalyzed by polymerase is described briefly at first. Oligonucleotides are prepared from activated nucleotides catalyzed by metal ions such as Pb2+ and Zn2+ which mimic the role of the metal ion at the active cite of the polymerase. Template-directed synthesis of oligonucleotides is described as a model reaction of nucleic acid replication. The metal ions, the template and the activated nucleotide used as a monomer affect the yield, chain length and regioselecivitv of the resulting oligonucletide.
