DNAの部位特異的な化学反応と分子認識
1982 年 40 巻 8 号 p. 735-743
詳細
1982 年 40 巻 8 号 p. 735-743
The molecular recognition of DNA by small molecules including bisintercalators has been described. Site-specific chemical reactions of DNA are next reviewed. These include i) reactions of DNA with oxygen-dependent antibiotics such as bleomycin, neocarzinostatin and camptothecin, and ii) single strand cleavage induced by artificial compound-metal-O2 systems. Sequence specific photoreaction between DNA and psoralenes is briefly discussed. A new method for selective removal of thymine from DNA utilizing photochemical reaction is also described in detail.
