Abstract
Recently, much attention has been focused on the syntesis of dehydrooligopeptides (DHP), containing one or more α-dehydroamino acid (DHA) residues, and the correlation between the structure and the bioactivity of DHP. The synthetic studies on DHP were reviwed according to the following articles :
1. Introduction.
2. Synthesis of dehydrodipeptides.
2.1. Synthesis of DHA as carboxy and amine components. 2.2. Stepwise elongation. 2.3. β-Elimination of dipeptide. 2.4. Synthesis of geometric isomer. 2.5. The other elimination methods. 2.6. The other new synthetic methods.
3. Synthesis of Dehydrooligopeptides.
3. 1. Fragment condensation. 3.2. Synthesis and reactivity of N-carboxy α-dehydroamino acid anhydride (Δ NCA). 3.3 Δ NCA as synthon.
3.4. Application of Δ NCA method.
4. Conclusion.
