チタン-窒素錯体を用いた有機合成反応の開発

新規N1ユニット試剤の開発研究

抄録

Molecular nitrogen was incorporated into organic compounds via titanium nitrogen complex [TiNMg₂Cl₂·THF]. Namely, the reaction of titanium isocyanate complex [3THF· Mg₂Cl₂OTiNCO] prepared from titanium nitrogen complex [TiNMg₂Cl₂·THF] and CO₂ with acid anhydrides afforded cyclic imides and quinazoline derivatives. Using the combination system of nitrogenation and palladium catalyzed carbonylation, phthalimide, isoindolinone, and quinazolines were synthesized from an aryl halide. Furthermore, coupling reaction of ketones with an aryl or vinyl halides in the presence of Pd (0) and titanium isocyanate complexes smoothly proceeded to give divinyl amines or arylvinyl amine via transmetalation.