糖と塩基との縮合反応によるヌクレオシド類の合成
1992 年 50 巻 6 号 p. 535-544
詳細
1992 年 50 巻 6 号 p. 535-544
Many nucleoside analogues, which lack 2'-substituents, have been known to be a useful compound as anticancer and anti-virus agents. On the other hand, synthesis of these derivatives utilizing the condensation reactions between sugars and nucleic bases have a difficulty in the stereoselectivity of these reactions. In this paper, our investigation on the condensation reactions with some 2-deoxysugars are discussed in the point of stereoselectivity. Transformations to 2', 3'-dideoxynucleosides and 2', 3'-didehydro-2', 3'-dideoxynucleosides are also described.
