二次構造のde novo designと機能性ペプチドの設計

抄録

Three dimensional structures of peptides and proteins are directly related to their biochemical functions. Since protein tertiary structures are considered to be an assembly of several secondary structures, considerable efforts have been directed toward the synthesis of short peptides that adopt a stable secondary structure. In recent years, various modeling and synthetic techniques for polypeptide structures have become easily accessible for synthetic organic chemists. The peptide design combined with synthetic organic chemistry has established a new class of molecules that judiciously use organic template molecules to assemble predetermined secondary structures of peptides. Functional aspects of these designed peptide/protein mimetics are also discussed.