異常アミノ酸を含有するペプチドの合成-ドラスタチン10を例として-

抄録

Synthetic studies on dolastatin 10, an antitumor marine peptide containing unusual amino acids, are reviewed. Strategies for the synthesis of the C-terminal dolaphenine (Doe) are first described, and then the stereoselective synthesis of the two unusual amino acids, dolaproine (Dap) and dolaisoleuine (Dil), is discussed. Finally, the method for the construction of the whole molecule by assembling each amino acid unit is described.