抄録
NMR studies employing oligonucleotides regio-selectively labeled with 15N-atom provide valuable information regarding nucleic acid structures, nucleic acids binding with drugs, and nucleotide-protein interactions. The potential utility of the 15N-labeled oligonucleotides has led to considerable interest in the development of synthetic routes to the required 15N-labeled nucleosides. In this paper, the synthetic methods of the labeled nucleosides are summarized.
