Palladium Catalysis in Water : Design, Preparation, and Use of Amphiphilic Resin-Supported Palladium-Phosphine Complexes

Abstract

Palladium-catalyzed synthetic transformations (π-allylic substitution, carbonylation, cross-coupling, etc.) were achieved in water by use of amphiphilic polystyrene-poly (ethylene glycol) resin (PS-PEG) -supported palladium-phosphine complexes. Asymmetric allylic alkylation of cyclic allyl esters was catalyzed by a palladium complex of a PS-PEG-supported chiral (imidazoindole) phosphine ligand with high enantioselectivity of up to 99% ee.