New Approaches to Stereoselective Synthesis of Fluorinated Amino Acids

Abstract

Novel synthetic strategies for the preparation of fluorinated amino acids are described. Asymmetric synthesis of fluoro amino acid derivatives was accomplished by (i) diastereoselective alkylation of chiral glycine Schiff bases, (ii) diastereoselective intramolecular cyclization of chiral γ-cyanohydrins and (iii) catalytic enantioselective hydrogenation of fluorinated iminoesters.