不斉非対称化法 : 多不斉中心の同時立体制御法
2002 年 60 巻 8 号 p. 732-739
詳細
2002 年 60 巻 8 号 p. 732-739
“Asymmetric desymmetrization” is an efficient and powerful methodology for optically active substances with complex structures. Enantiotopic group differentiation reactions starting from meso compound with chiral centers can afford chiral/non-racemic compounds bearing controlled multi-chiral centers. We introduce many useful examples of asymmetric desymmetrization, which have ever been reported, and our results on asymmetric desymmetrization using asymmetric ene reactions catalyzed by chiral BINOL-Ti complex.
