New Development of Multi-Component Reactions Using Transition Metal Compounds

Abstract

Recently, transition-metal promoted multi-component reactions have attracted much attention as powerful tools for onepot construction of complex molecules with high efficiency. For example, a number of couplings of three multiple-bonds via the formation of metallacycles using early transition metals have been reported. Late transition metal-catalyzed fourcomponent reactions involving catalytic cycles with combination of oxidative addition-reductive elimination have been investigated. Metathesis using the Grubbs catalysis is also embedded to the multi-component reactions.