Attention deficit hyperactivity disorder (ADHD) is a major psychiatric disorder characterized by hyperactivity, inattention, and impulsivity. ADHD is also observed in dogs. The most frequently prescribed drug used to treat ADHD is methylphenidate, which acts on the dopamine transporter to increase the release of dopamine, and thus highlights the potential role of the dopamine transporter in ADHD pathogenesis. Because dopamine plays a key role in ADHD, we determined the DNA sequences of the dopamine transporter gene, SLC6A3 in 22 beagle dogs. With regard to ADHD score, behavioral questionnaires were also administered to their handlers. Polymorphisms at four sites were identified in the SLC6A3 gene. Dogs with genotypes AA in A157T; GG in G762A; or those ≤2 years old had higher scores of inattention. Dogs that were ≤2 years old also had higher scores of motor activity and impulsivity. These results suggest that ADHD in dogs is associated with the dopamine transporter. However, further studies are required in order to establish this fact.
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