Objetive: Malignant lymphoma is an HIV-associated complication secondary to Kaposi's sarcoma. Its incidence, particularly of the non-Hodgkin disease type, in patients with HIV is more than sixty times that in healthy persons, and is increasing. Here, we report one case of incipient oral non-Hodgkin malignant lymphoma in a patient with HIV.
Case Report: In late December, 2003, a 40-year-old man with HIV presented at our infection department with a mass on the maxillary left alveolar gingiva. He was later treated at a dental clinic, but showed no improvement, so on January 26, 2004, he returnedto our hospital. At first, the lesion measured 15 × 10 mm and had a clearly demarcated border. There was an elastic hard mass-like sarcoma on the maxillary buccal gingiva. We found obscure erosion on the hard palate. We suspected that the mass was a maxillary gingival tumor, so we performed a biopsy. The diagnosis revealed a diffuse large B-cell lymphoma. He was admitted to the infection department of our hospital on March 8, 2003.
Conclusion: A CT scan revealed lymphadenopathies measuring 15 mm on his neck and groin. Isotopic examination concentrated on the left maxillary gingiva. His CD4 was 104/μl, and his HIV-RNA was1.1×10⁶copies/ml. Treatment was commenced with HAART (dT4, 3TC, NFV) on March 9, 2004, and 75% EPOCH on March 23, 2004. After completion of one course, his oral mass disappeared, and CT showed a contraction of his neck lymphadenopathy. He was given six courses of EPOCH, finishing on July 16, 2004. On completion, isotopic examination revealed no thickening of his left hard palate. HAART was continued until July 2006, at which time his condition was good and with no evidence of recurrence of malignant lymphoma.

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