This study investigated the effect of implant timing on bone tissue reactions after placement of hydroxyapatite-coated implants into the tibiae of ovariectomized rats. Female Wistar rats, aged 12 weeks, were subjected to bilateral ovariectomy or sham surgery. Seven or 21 days after surgery, implants were placed in the proximal part of the tibia. Rats were killed 14 days after implantation, and bone tissue reactions were examined histologically. Only a slight difference was noted between ovariectomized and sham-operated rats in bone formation around implants and at areas of contact between hydoxyapatite and bone. In ovariectomized rats, newly formed bone trabeculae tended to decrease more rapidly than in sham-operated rats ; the decrease was especially rapid in rats that had received implants 21 days after ovariectomy. Therefore, bone resorption might progress more rapidly around implants placed the usual interval after ovariectomy than around implants placed earlier after ovariectomy. These results suggest that the application of dental implants to postmenopausal patients who have increased bone turnover must be carefully considered with respect to bone resorption around the implant.
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