Westernization of lifestyles among Japanese, in particular among young generations, is a matter of concern for future increase in coronary heart disease. We surveyed a total of 349 male university students to examine changes in lifestyles and coronary risk factors in campus life. We compared dietary habits and serum fatty acid compositions as well as other coronary risk characteristics between freshmen (n=171) and fourth-year (senior) students (n=178). Serum fatty acid compositions and dietary intakes of selected foods as well as serum lipids, blood pressures and physical characteristics were examined at the 1996 and 1997 annual health examinations.
Compared to freshmen, senior students had a lower frequency of fish, vegetable, milk and egg intake, and a higher frequency of oil and fat intake. The proportions of serum saturated and monounsaturated fatty acids were significantly higher among senior students than among freshmen, whereas the proportion of serum polyunsaturated fatty acids was significantly lower among senior students than among freshmen. Senior students also had higher systolic and diastolic blood pressures, percent body fat, smoking rate and alcohol usage than freshmen. Mean body weight and mean body mass index were not different between the two groups.
Senior students generally showed Westernized dietary habits and higher coronary risk profiles than freshmen as indicated by the change of serum fatty acid compositions. Modification of these dietary habits and lifestyles may be important for the prevention of future CHD among Japanese young adults.

View full abstract

Objectives: To determine the relationship between obesity and cardiac autonomic nerve activity in healthy children. Methods: 16 healthy male children comprising of 9 nonobese and 7 obese subjects (body mass index > 19.1 kg/m²) aged 8−9 years were selected. Electrocardiograms were measured for 10 min. under controlled ventilation (0.25 Hz) in the supine position. Consecutive 256-second RR interval data were transformed by the Fast Fourier Transform method into power spectral data. Very low frequency (VLF; 0.003−0.04 Hz), low frequency (LF; 0.04−0.15 Hz), high frequency (HF; 0.15−0.40 Hz), and total power (TP; 0.003−0.40 Hz) were calculated and transformed into a natural logarithm (ln). Normalized units (nu) were also calculated as follows: LFnu = LF / (TP - VLF) x 100. HFnu = HF / (TP - VLF) x 100. Low/high-frequency ratio (LHR) was calculated as LF divided by HF. Unpaired t test was performed to compare the 2 groups.
Results: TP ln and HFnu, reflecting cardiac parasympathetic nerve activity, in obese children were significantly lower than those in nonobese children. In contrast, LFnu and LHF, reflecting cardiac sympathetic nerve activity, in obese children were significantly higher than those in nonobese children.
Conclusions: These findings suggest that obese children have higher sympathetic nerve activity and lower parasympathetic nerve activity than nonobese children.

View full abstract

Consumed substances, including food, drink, and tobacco, produced in the environment are exposure sources of Cd. The object of the present study was to estimate Cd exposure and absorption amount from smoking cigarettes, one exposure source of Cd, using recent findings from Japan. The market share of cigarettes produced in foreign countries has increased in Japan, the proportion of tobacco leaves harvested in foreign countries has increased in cigarettes produced in Japan, and the percentage of smokers in Japan has changed. Therefore, obtaining the absorption value of Cd from smoking cigarettes using recent findings from Japan is significant.
We collected information on (1) the concentrations of Cd in tobacco leaves by country of harvest and in cigarettes by country of production, (2) the concentrations of Cd in cigarette smoke, (3) the proportion of tobacco leaves harvested in foreign countries used in cigarettes made and sold in Japan, (4) the absorption rate of Cd in the airways for cigarette smoke, (5) the smoking rate by gender, age, and year in Japan, (6) the number of cigarettes sold in Japan by year and country of production, (7) the number of cigarettes smoked by smokers per day according to gender and age in Japan, and (8) the population size in 1998 by gender and age in Japan. The mean amount of Cd absorbed via the airways by smoking for smokers in Japan was calculated to be 0.89-1.78 μg/day from the above information. The values are not small in comparison with the amount of Cd absorbed from the digestive organs.
The concentration of Cd in tobacco leaves harvested in Japan and cigarettes produced in Japan is generally higher than that of leaves harvested and cigarettes produced in foreign countries. The increase in the market share of cigarettes produced in foreign countries and sold in Japan and the increase in the proportion of tobacco leaves harvested in foreign countries used in cigarettes made and sold in Japan have decreased the amount of Cd absorbed by smoking for smokers in Japan.

View full abstract

A new fogging disinfection method was evaluated as a means of disinfecting ward rooms and operating theaters. A temporary room was established where the disinfection effect of fogging was examined. Based on the results, an automatic fogging disinfection unit was developed. This unit was then used in the disinfection of operating theaters, where its safety and effectiveness were examined.
To evaluate the results of disinfection, bacterial culture tests were performed on the floor, walls and other areas of the operating theater, and the number of colony forming units was used as an index of effectiveness. Benzalkonium chloride, alkyldiaminoethylglycine, sodium hypochlorite, glutaral and acidic electrolytic water were used for the operating theaters. The average disinfection effect was 90% or better for all disinfectants, except acidic electrolytic water.
The newly developed automatic fogging disinfection unit enables safe and effective disinfection, and may be suitable for disinfecting ward rooms and operating theaters.

View full abstract

Objective: For 1,361 victims of the Great Hanshin-Awaji Earthquake, to evaluate the usefulness of seismic intensity information for mental health activities, we examined the quantitative relationship between experienced seismic intensity and earthquake-related life events or mental health. Methods: Questionnaires were administered concerning seismic intensity, life events and mental health to the victims.
Results: The incidence of serious life events, such as death of a close family member and mental disorders were higher in areas of high seismic intensity than in low-intensity areas. Victims who experienced intensity 7 (Japan Meteorological Agency) scored 11 or more on the Modified Mercalli (MM) scale, perceived more depressive symptoms [odds ratio (OR) 2.11, 95% confidence interval (95% CI), 1.49−2.98)] and lower mental health status (OR 1.87, 95% CI 1.34−2.61) than those who suffered intensity 4 or less, who scored 7 or less on MM scale after controlling for various sociodemographic factors.
Conclusions: Higher seismic intensity was associated with each severe life event and ill mental health among earthquake victims.

View full abstract

Objectives: The goal of the present study was to investigate the relationship between occlusal function and body composition in 108 premenopausal healthy Japanese women aged 20−45 years.
Methods: Pressure-sensitive sheets were used to measure occlusal function. Whole fat mass and lean mass, fat-free mass, and whole-bone mineral content were measured by dual-energy X-ray absorptiometry (DXA).
Results: After being adjusted for age and the square of height, the whole lean mass and grip strength of the large occlusal contact-area group were found to be significantly higher than those of the small occlusal area groups (p<0.05, respectively). In the 1-year follow-up study, changes in weight in the small-occlusal contact-area group and the low-occlusal force group were significantly larger than other occlusal-contact area or occlusal-force groups. The mean occlusal-contact area and occlusal force were both significantly smaller in subjects with partial dentures than in those without (p<0.05).
Conclusion: Large occlusal contact-area, high occlusal force, and no dentures may be associated with some good health conditions in premenopausal Japanese women.

View full abstract

The purpose of this study was to examine the relationships between peak bone mass and genetic and environmental factors. We measured whole-body bone mineral density (BMD), lumbar spine BMD, and radius BMD with dual-energy X-ray absorptiometry (DXA) and analyzed eight genetic factors: vitamin D receptor (VDR)-3', VDR-5', estrogen receptor (ER), calcitonin receptor (CTR), parathyroid hormone (PTH), osteocalcin (OC), apolipoprotein E (ApoE), and fatty acid binding protein 2 (FABP2) allelic polymorphisms using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLPs). We also surveyed menstrual history, food intake, and history of physical activity using questionnaires.
After adjusting for age, body mass index (BMI), current smoking status, current Ca intake, alcohol intake, menoxenia, and physical activity, the mean BMD in subjects with the HH/Hh genotype was significantly higher than that of subjects with the hh genotype for whole-body BMD (mean±SD, 1.20±0.10 vs. 1.18 ±0.09 g/cm²; HH/Hh vs. hh, p=0.04) and at lumbar spine BMD (mean±SD, 1.18±0.14 vs. 1.14±0.12 g/cm²; HH/Hh vs. hh, p=0.02) in OC allelic polymorphism. Furthermore, the results of multiple regression analyses taking the 8 genetic factors plus the 7 environmental factors listed above into account showed that the strongest factor contributing to BMD was BMI at any site (whole-body and lumbar BMD p<0.0001, radius BMD p=0.0029). In addition, OC polymorphism (p=0.0099), physical activity (p=0.0245), menoxenia (p=0.0384), and PTH polymorphism (p=0.0425) were independent determinants for whole-body BMD, and OC polymorphism (p=0.0137) and physical activity (p=0.0421) were independent determinants for lumbar BMD and radius BMD, respectively.

View full abstract

A total of 206 residents (76 males and 130 females) of a rural area of Hokkaido, Japan, attending a health check in August, 1997, were studied to assess the relationship between serum carotenoids and atrophic gastritis (AG). Of the participants, 91 had AG, as indicated by their serum levels of pepsinogen I and pepsinogen II. Logistic regression analysis, after adjusting for gender and age, revealed that the odds ratios for serum carotenoid levels were lower for subjects with high serum levels of α-carotene (odds ratio, 0.41; 95% C.I., 0.19−0.88) and β-carotene (odds ratio, 0.41; 95% C.I., 0.18−0.91) than for those with low serum carotenoid levels. In addition, the odds ratios of subjects with high serum levels of β-cryptoxanthin (odds ratio, 0.60; 95% C.I., 0.28−1.31), provitamin A (odds ratio, 0.38; 95% C.I., 0.17−0.85), and retinol (odds ratio, 0.67; 95% C.I., 0.31−1.48) were found to be lower than the odds ratios for those with low serum levels. Odds ratios for subjects with high serum zeaxanthin/lutein levels were higher than odds ratios for those with low serum levels. These results suggest that frequent intake of foods rich in carotenoids with provitamin A activity may reduce the risk of AG.

View full abstract

Objective: Although the Japanese EuroQol instrument was developed in 1998 by a Japanese translation team, the reliability of health state valuations of the fuller questionnaire has not yet been investigated in Japan. We carried out a pilot study to investigate the reliability of health state valuations of the Japanese EuroQol instrument.
Methods: The survey was conducted twice with the fuller questionnaire of the Japanese EuroQol instrument in a class of preventive medicine. We analyzed test-retest reliability based on the health state valuations and calculated Cronbach’s coefficient alpha of both tests.
Results and Conclusions: The mean valuations of 14 hypothetical health states and ‘death’ between test and retest were not significantly different by paired t-test. The reliability by calculated correlation between test and retest was 0.996 (p<0.0001). In addition, Cronbach’s coefficient alpha of the first test was 0.827, and that of the second test was 0.865. Although good reliability was shown in the present study, our conclusion was limited to applications of population-based surveys because of the small number and limited subjects of the present study. Further investigations are required in the form of a population-based survey.

View full abstract

Life expectancy does not necessarily match quality of life (QOL). A cohort study involving a population of 10,107 in a certain city of Japan was conducted to evaluate active life expectancy (ALE), which has a direct relationship with QOL. The ALE that took functional recovery rates into account was 17.20 and 19.08 years for males and females respectively, at the age of 65. These values increased by 2.98 and 3.87 years for men and women, respectively, compared with when functional recovery rates were not considered. ALE may serve as an indicator for the objective evaluation of various public health services provided by local governments.

View full abstract