This paper summarizes the results of a course to develop employability skills and cross-cultural communication of international and Japanese students through lectures, internships, involvement with corporate employees, business planning aiming to achieve the SDGs, and career vision formation. Then the paper examines whether this course can cultivate a “transformation mindset,” which is the mindset to produce results regardless of the environment and situation. In this course titled “SDGs and Business Solutions for International and Japanese Students,” international and Japanese students work as a team to deepen their understanding of the SDGs and create business plans to achieve them. Through theoretical study, collaboration in diverse groups, and 30 hours of internship activities, students deepen their understanding of Japanese corporate culture and develop employability skills. In addition, company employees support students as mentors. The course is designed to help students and employees recognize the potential and value diversity brings in a team composed of members from different cultural backgrounds. The results of the Transformation Mindset Scale and the analysis of the students’ reflective journal suggest the growth of “Human Relations and Teamwork,” “continuous learning,” and “resilience.”