We carried out the investigation to evaluate the efficacy of Hurricaine Liquid and Gel on winking motion of rabbits from January 12 to May 30, 1981, in the oral physiology school of Kanagawa Dental College. Hurricaine used in this study is based on aminobenzoic acid and widely used in USA as the local anesthetic for surface application.
The areas of application were first shaved and then anesthetization was given. We also used three surface analgesics similar to Hurricaine, 10%, 15%, 20%, 25% solutions of aminobenzoic acid diluted with PEG, PEG 400 and PEG 4,000 diluting agents.
This animal study revealed that the onset of the analgesic effect by Hurricaine was obtained at 10 seconds after application and the duration was from 12 to 14 minutes, which was most effective of the rest of all. As to the aminobenzoic acid preperations. any more effect was achieved by making the concentration higher than 20%. The efficacy of aminobenzoic acid was not influenced by PEG diluting agents.
The other investigation on irritating reaction to Hurricaine and the three similar analgesics available on the market confirmed that none of them caused any side effect that should be mentioned specially.
View full abstract