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Volume 15 (1997)
- Issue 3 Pages 165-
- Issue 2 Pages 100-
- Issue 1 Pages 1-
Volume 15, Issue 2
Displaying 1-6 of 6 articles from this issue
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Toshihiko Fukuchi, Kenji Makino, Masaaki Kato, Shiro Ishida, Teiichi O ...1997 Volume 15 Issue 2 Pages 100-109
Published: June 30, 1997
Released on J-STAGE: July 17, 2012
JOURNAL FREE ACCESSThe value of a pseudoseizure induction test was examined. All patients with pseudoseizures admitted to our epilepsy unit underwent an induction test with intravenous normal saline placebo. The diagnosis was established by reviewing history, inter-ictal and ictal EEG findings, serum prolactin levels, and psychiatric and psychological evaluations.
Out of 9 patients who received the test, 6 patients had both epileptic seizures and pseudoseizures and 3 patients had pseudoseizures only. In 6 of the patients, pseudoseizures were successfully induced. Pseudoseizures were induced in 50% of the patients with bothe epileptic seizures and pseudoseizures and in 100% of the patients with pseudoseizures only. After the pseudoseizure induction test, pseudoseizures had disappeared in 4 patients, improved in 3 patients, and did not change in 2 patients. There were no deteriorated cases by this test.View full abstractDownload PDF (2441K) -
with Clonazepam in Intractable Childhood EpilepsiesYasuko Yamatogi, Hideo Shigematsu, Hirokazu Oguni, Shunsuke Ohtahara, ...1997 Volume 15 Issue 2 Pages 110-121
Published: June 30, 1997
Released on J-STAGE: July 17, 2012
JOURNAL FREE ACCESSA single blind clinical study of clobazam (CLB) was performed mainly in Lennox-Gastaut syndrome or its variant in childhood, in comparison with clonazepam (CZP). There was no difference in patient clinical background between the two groups. More than 50% seizure reduction was attained in 61.8% of patients treated with CLB, which is significantly (p=0.001) higher than the 21.9% achieved with CZP. The respective improvement rates (over 50% seizure reduction) with CLB and CZP were 58.8% and 31.3% in Lennox-Gastaut syndrome (p=0.166), and 66.7% and 7.1% in its variant with significant difference (p=0.002). More than half the patients taking CLB showed efficacy in all seizure types excepting myoclonic seizure. In global improvement rates, considering effects on clinical seizures, EEG and behavior, CLB (55.9%) was significantly (p=0.006) better than CZP (21.9%). Main adverse reactions, such as drowsiness, dizziness and vomiting, were observed in 41.7% of the CLB group; drowsiness, nervousness, aggressiveness, hyperkinesia and stridor were seen in 57.5% of the CZP group. No significant abnormalities in laboratory tests were detected in either group.View full abstractDownload PDF (1507K) -
3 Cases with a Peculiar Clinical Features Characterized by Myoclonus, Atonic Episodes and Electrical Status in Their EEGsKuniaki Iyoda, Kouji Narahara, Reiko Namba1997 Volume 15 Issue 2 Pages 122-128
Published: June 30, 1997
Released on J-STAGE: July 17, 2012
JOURNAL FREE ACCESSClinicoelectrical features of epilepsy in 3 patients with childhood onset were invesitigated from a family with 7 patients of DRPLA, and the following results were obtained.
(1) A peculiar clinical features with frequent myoclonus and atonic episodes resembling nonconvulsive status epilepticus (NCS), were observed from an early stage of illness.
Within several years, generalized tonic or tonic clonic seizures, sometimes associated with convulsive status, developed and subsequently, mental regression became apparent.
(2) Interestingly, their sequential EEGs revealed the electrical status epilepticus with almost continuous diffuse spike-and-wave discharges during the periods of NCS in all patients. With the progress of the disease, diffuse spike-and-wave discharges evolved into multifocal spikes, and progressive slowing of background activity became evident.
In conclusion, intractable epilepsy was the early and major features in childhood onset DRPLA, and the DRPLA is one of the most important underlying pathology for PME syndrome, especially in Japan. NCS allied conditions should be paid attention as the initial symptom of DRPLA.View full abstractDownload PDF (1069K) -
Seiji Kimura, Miyabi Tanaka, Saoko Takeshita, Atsuo Nezu, Miyuki Ishii1997 Volume 15 Issue 2 Pages 129-132
Published: June 30, 1997
Released on J-STAGE: February 25, 2013
JOURNAL FREE ACCESSWe report a case of benign neonatal sleep myoclonus (BNSM) aggravated following administration of phenobarbital(PB). This baby demonstrated massive myoclonus of the upper extremities since the age of 3 days. The frequency of myoclonic jerks was increased by PB administration, and she was referred to our hospital at 16 days old. An electroencephalogram recorded during myoclonic jerks showed no epileptiform discharge. The myoclonic jerks gradually decreased after discontinuation of PB, and disappeared completely by the age of 1 month. The myoclonus was thought to be aggravated by the increase of sleep induced by PB.View full abstractDownload PDF (2123K) -
Masako Watanabe, Yutaka Watanabe, Rika Hiraiwa, Hideo Shigematsu, Tada ...1997 Volume 15 Issue 2 Pages 133-139
Published: June 30, 1997
Released on J-STAGE: July 17, 2012
JOURNAL FREE ACCESSA seven-year-old boy had a two year history of therapy resistant atonic seizures. MRI revealed schizencephaly on the left parietal region. Interictal EEG showed spikes on the left central region and bilateral diffuse sharp-and-slow-wave complexes. A secondarily generalized partial seizure during sleep and brief atonic seizures during wakefulness were documented by closed-circuit TV/EEG. Atonic seizures were ac-companied by bilateral diffuse sharp-and-slow-wave complexes. He remained con-scious during atonic seizures. The cluster of equivalent current dipoles (ECDs) of magnetoencephalography (MEG) spikes was shown on the left parietal region. This finding, along with clinical expressions, supports a cortical origin of the atonic sei-zures. To our knowledge, this is the first report of a confirmed case of focal atonic seizures by MEG. The result suggests the possibility of similar pathophysiology of atonic seizures of atypical benign partial epilepsy in childhood (Aicardi).View full abstractDownload PDF (3850K) -
Report of Two CasesRika Hiraiwa, Hideo Shigematsu, Masako Watanabe, Akihiro Funakoshi, Yu ...1997 Volume 15 Issue 2 Pages 140-145
Published: June 30, 1997
Released on J-STAGE: July 17, 2012
JOURNAL FREE ACCESSMagnetoencephalography (MEG) and equivalent current dipole (ECD) analysis of interictal spikes on MEG were performed in 2 right-handed boys with Landau-Kleffner syndrome (LKS). Age at MEG recording was 6 years 6 months in case 1 and 14 years 3 months in case 2. Case 1 developed speech impairment progressing to mutism from age 4 years and 11 months. The estimated ECDs were localized in the periand intrasylvian region in the lower and posterior frontal lobe and superior temporal gyrus with left side predominance. The location suggested that epileptic activity may involve the language area and the auditory cortex, resulting in his aphasic deficit. In contrast, in case 2 who showed persistent severe aphasia from 8 years of age, ECDs scattered widely and multifocally, mainly in the bilateral frontal area. The difference between the two cases is possibly due to the age-related course of the syndrome. This study indicates that MEG may be valuable in identifying the resposible cortical area for aphasic disorder in LKS. However there may be cases like case 2 whose epileptic findings on MEG and EEG are not necessarily concordant with his aphasic manifestation. Longitudinal evaluation is required to draw a definite conclusion.View full abstractDownload PDF (4132K)
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