Mirtazapine significantly reduces suicide risk and is likely to cause an increase in appetite compared to other antidepressants. No known causes of suicide attempts or risk factors for increased anxiety and agitation after mirtazapine administration have been reported. In this report, we discuss a case of increased appetite that resulted in a suicide attempt. The patient, a man in his seventies who had been diagnosed with depression, was admitted to the hospital and treated with 30 mg of mirtazapine and electroconvulsive therapy (ECT). However, he did not go into remission. After being discharged from the hospital, the dose of mirtazapine was increased to 45 mg. A week later, his increased appetite became noticeable. Additionally, he sustained injuries when he leapt from the second floor of his house. He was transported to our hospital, and his consciousness was clear at the time of the initial examination. He informed us that his increased appetite was the catalyst for his attempted suicide. His anxiety and agitation were obvious, and we had to interrupt the interview several times when he complained of increased appetite. We suspected drug-induced anorexia, discontinued the mirtazapine, and started 10 mg of escitalopram. Following that, his complaints of anxiety, agitation, and increased appetite were significantly reduced. Later, he was admitted to a rehabilitation hospital. Through our experience with this case, we learned that one of the causes of suicide attempts is increased appetite and agitation.
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