It is desirable to avoid drug use during pregnancy considering the effects on the fetus and newborn. However, some women may need drug treatment for illness before pregnancy or during pregnancy. This study aims to obtain information on drug selection in drug therapy for pregnant women, focusing on neonatal drug withdrawal syndrome (NAS).

Therefore, we analyzed the expression tendency of NAS using the “Japanese Adverse Drug Event Report database (JADER)” in single-agent and multiple-drug administration. The drugs reported to cause NAS were psychotic drugs such as antidepressants and antianxiety drugs. As a result of analyzing the drug onset tendency in single-agent administration, escitalopram oxalate, alprazolam, and zolpidem tartrate were more likely to cause onset than other drugs. In the comparison of monotherapy and multiple drug therapy of each drug, aripiprazole was more likely to cause onset in two-drug use, and risperidone, quetiapine fumarate, sodium valproate, sertraline hydrochloride, fluvoxamine maleate, and paroxetine hydrochloride hydrate in three- or more drug use. In addition, 7 cases were “unrecovered” and “with sequelae” in multiple drug use, which was higher than in the case of single agent administration. Therefore, it is necessary to pay attention to the onset and aggravation of the disease due to multiple drug use. We believe that these results will help drug selection in drug therapy for pregnant women with psychiatric disorders.

As of 2017, more than half of elementary and junior high schools in Japan spent the summer without air conditioning, and although it was assumed that the environment inside classrooms during the summer was uncomfortable, the actual situation was not fully understood. In this study, temperature and wet bulb globe temperature (WBGT), an indicator of the risk of heat stroke, were monitored over time in the classrooms of an elementary school in Toyama city from September 2017 to July 2018 in order to determine the actual condition of the children's learning environment. The classrooms in the reinforced concrete building were the hottest in July among the days when children attended school, with temperatures in the classrooms up to 9.6℃ higher than the outside temperatures. Even though the temperatures were within the standard range, the WBGT levels were sometimes higher than the warning level. In order to create a comfortable learning environment for children during the summer, it is necessary to install air conditioners and control WBGT.