Introduction: The optimal timing for initiating and discontinuing oral propranolol therapy for infantile hemangioma has not yet been established. However, there are extensive reports on the use of propranolol for treating conditions other than infantile hemangioma.
Methods: We conducted a cross-disciplinary literature review of adverse events associated with propranolol treatment in pediatric diseases other than infantile hemangioma to assess the risk of oral administration.
Results: Propranolol was administered to patients with hypertension, cardiac disease, and retinopathy of prematurity. Adverse events, including bradycardia, wheezing, and hypoglycemia, occurred at a frequency of 10%-15%. These events required discontinuation, dosage adjustments, and specific treatments. Various recommendations from different medical specialties have been made to maximize the efficacy and safety of propranolol.
Conclusion: To ensure the safety of propranolol treatment in neonates, continuous monitoring of vital signs and dosage adjustments are necessary during early propranolol administration. Adherence to medication, management of oral caloric intake, and addressing adverse events are crucial for cases where treatment continues beyond the involution phase of infantile hemangioma. These findings provide valuable insights for shaping treatment strategies for infantile hemangioma patients.
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