Rationale During disasters, many are injured simultaneously and medical staff and resources may be in short supply. In this case, intravenous therapy is often difficult to administer at the disaster site. Recently, intravenous therapy has been substituted by oral rehydration solution (ORS), which is typically used to treat diarrhea and heatstroke. ORS is easier to administer, and water and electrolytes are quickly absorbed. In this study, we examined the effects of ORS in two animal models requiring intravenous therapy (hemorrhagic model and crush syndrome model).
Methods Hemorrhagic model: intravenous tube was introduced in jugular vein of rats and body weight was decreased 2% by de-blooding. The rats were then given a test solution intravenously or orally. Crush syndrome model: Both hindlimbs of anesthetized rats were compressed for 2 hours. After the weight was removed, the rats were given a test solution intravenously via a jugular vein or orally.
Results Hemorrhagic model: Plasma volume was recovered by intravenous therapy. In ORS group, plasma volume significantly recovered but the effect was weaker than intravenous group. Crush syndrome model: Blood levels of potassium, hematocrit, BUN, and myoglobin increased significantly in the control group but not in the group that received lactated Ringer's solution (LR). Kidney function parameters increased in the group that received MES compared to those in the LR group. In the ORS group, levels of hematocrit, BUN, and myoglobin were lower than those in the control group and lower.
Conclusions These results suggest that ORS can be a useful substitution for intravenous solution. In situations such as disasters, intravenous therapy may not always be possible onsite even when a patient should be rehydrated as quickly as possible. When intravenous therapy cannot be started, ORS is effective for maintaining fluid volume and renal function until the patients reach a hospital.han those in the animals that received mineral water.
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