Single oral administration of anti-arrhythmic drugs can control symptoms and risks of atrial fibrillation (AF) and can also prevent adverse events due to long-term treatment with anti-arrhythmic drugs. We evaluated the efficacy and safety of single oral administration of flecainide and propafenone in Japanese AF patients. Twenty-nine paroxysmal AF patients were enrolled and randomized to single oral administration of flecainide 100 mg (Group-F, n=15 ; 65±15 years old) or propafenone 150mg (Group-P, n=14 ; 61±12 years old). There were no significant differences in characteristics between Group-F and Group-P patients. The time-course of heart rate, blood pressure, QRS duration, and QTc interval did not change during the observation period (120 min) in each group. The defibrillation success rates during the observation period were 20% (3/15) in Group-F and 50% (7/14) in Group-P (p=0.09) ; the average time from single oral administration to sinus recovery was 70±17 min and 77±34 min, respectively (p=0.74). Only one patient developed atrial flutter in Group-F. In the present results, Group-F tended to show a lower defibrillation success rate than Group-P although the difference did not reach statistical significance. Flecainide 100mg and propafenone 150 mg can be safely utilized for single oral administration in Japanese AF population.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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