While radical nephroureterectomy was previously the gold standard treatment for nonmetastatic upper tract urothelial carcinoma, owing to recent endourologic progress, kidney-sparing management including ureteroscopic treatment has become widespread. According to the NCCN guideline, favorable clinical and pathologic criteria for nephron preservation include : a papillary, unifocal, low-grade tumor, and size less than 1.5 cm, where cross-sectional imaging shows no signs of the presence of invasive disease. On the other hand, according to the EAU guideline, endoscopic ablation should be considered in the presence of clinically low-risk cancer, unifocal disease, tumor size < 2 cm, negative for high-grade cytology, low-grade URS biopsy, and no invasive sign on CT. Kidney-sparing surgery, including ureterscopy or segmental ureterectomy, can be considered on a case-by-case basis for high-risk patients with indications such as solitary kidney, bilateral UTUC, chronic kidney disease, or any other comorbidity compromising the use of RNU. Among patients with non-metastatic, cT1, or lowe-stage UTUC diagnosed in 2004-2012 collected from the National Cancer Database in the United States, 19.7% of patients with low-grade tumors and 6.4% of those with high-grade tumors underwent endoscopic treatment. The proportion of patients receiving definitive endoscopic treatment increased gradually.
Endoscopic techniques include cystoscopy, retrograde pyelography, semi-rigid ureteroscopy, flexible ureteroscopy, biopsy, laser ablation, and indwelling of a ureteral stent. Close attention should be paid to prevent a guidewire or ureteroscope from traumatizing the urothelium before its observation under direct vision.
Refined techniques for diagnosis and treatment by ureteroscopy will facilitate improved clinical outcomes including renal preservation and survival. We believe that ureteroscopic treatment for UTUC will continue to evolve and become applicable to a wider selection of patients.
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