We report a 65-year-old man with Li-Fraumeni syndrome-like families(LFL)who was suffering from multiple primary malignant tumors in six organs(lung, stomach, skin, kidney, urinary bladder, thyroid gland). The first cancer was left renal cancer at the age of 43 years old. There were six cancer patients among his relatives and we considered that his disease was caused by a hereditary factor. As a result of genetic testing, it became clear that he carried a germline mutation of c.733G > A, p.G245S in the
TP53 gene. Therefore, he and his relatives are at high risk of hereditary cancer. As a surveillance program for LFS has not yet been established, careful genetic testing of the relatives of this family is necessary, and should be carried out continuously in order to detect and treat cancer in the early stage.
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