The clinical results and the changes of physical properties of synovial fluid after intraarticular injection of sodium hyaluronate (SH, Artz (R) ) in patients with rheumatoid arthritis (RA) are reported. Eleven knee joints of 11 RA patients received intra-articular injection of 25mg of SH once a week for five weeks. This treatment was clinically evaluated with respect to pain, activities of daily living, swelling and range of motion. The activities of daily living were significantly improved, and pain and swelling were ameliorated in half, although the range of motion in such cases was only 18%.
We also evaluated the effects on the physical properties of synovial fluid, namely, hyaluronate concentration, hyaluronate molecular weight, viscosity, stringing, protein concentration, protein pattern and the number of leucocytes. Hyaluronate concentration, hyaluronate molecular weight, viscosity and stringing were distinctively improved.
We concluded that intra-articular injection of SH should be considered as having the possibility of being an effective local treatment for patients with RA.
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