Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

Displaying 301-350 of 374 articles from this issue

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Poster Presentations

Distinct glial responses to diverse chemical neurotoxicants in the striatum as monitored by imaging agents

Bin Ji, Makoto Higuchi, Jun Maeda, Motoki Inaji, Takashi Okauchi, Ming ...

Session ID: 30PE-22
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_324_2

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A NEW METHOD FOR THE PREDICTION OF CLINICAL CYP3A INDUCTION

Akihisa Kaneko, Motohiro Kato, Nobuo Sekiguchi, Kunihiro Ohta, Atsuko ...

Session ID: 30PE-23
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.325.1

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Evaluation of CYP3A4 induction using long term cultured human hepatocytes

Shintaro Nakayama, Daisuke Nakai, Yoko Nagai, Misa Hoshi, Taro Tokui, ...

Session ID: 30PE-24
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_325_2

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INHIBITORY POTENTIALS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AGAINST UDP-GLUCURONOSYLTRANSFERASE 2B7 IN HUMAN LIVER MICROSOMES

Yuji Mano, Takashi Usui, Hidetaka Kamimura

Session ID: 30PE-25
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.326.1

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EFFECT OF SULFONAMIDES ON PHARMACOKINETICS OF TOLBUTAMIDE IN RATS RECEIVING PERITONEAL DIALYSIS

Takashi Makita, Yuki Izuwa, Yukiko Komori, Tetsuya Aiba, Hiromu Kawasa ...

Session ID: 30PE-26
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_326_2

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FUNCTIONAL CHARACTERIZATION OF MATE1 AND MATE2, ORGANIC CATION/H+ANTIPORTERS, OF HUMAN

Kin-ya Ohta, Katsuhisa Inoue, Hiroaki Yuasa

Session ID: 30PE-27
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.327.1

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TRANSPORT OF MYCOPHENOLIC ACID AND ITS GLUCURONIDE VIA HUMAN RENAL ORGANIC ANION TRANSPORTERS hOAT1 AND hOAT3

Yoshie Tsuji, Yuichi Uwai, Hideyuki Motohashi, Toshiya Katsura, Ken-ic ...

Session ID: 30PE-28
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_327_2

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INVOLVEMENT OF ORGANIC ANION TRANSPORTERS IN THE RENAL SECRETION OF TOPOTECAN

Shinichi Matsumoto, Kenji Yoshida, Tomoji Maeda, Ikumi Tamai

Session ID: 30PE-29
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.328.1

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ROLE OF ORGANIC ANION TRANSPORTERS ON PHARMACOKINETICS OF ZONAMPANEL, AN α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONATE RECEPTOR ANTAGONIST, IN RATS

Tsuyoshi Minematsu, Tadashi Hashimoto, Takashi Usui, Hidetaka Kamimura

Session ID: 30PE-30
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_328_2

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Nuclear receptor mediated upregulation of MDR1 mRNA expression and functional activity by Sho-saiko-to

Akira Yamamoto, Nobuhiro Nishimura, Tomochika Uemura, Kohji Naora, Kik ...

Session ID: 30PE-31
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.329.1

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A New Strategy of High-Speed Screening and Quantitative SAR Analysis To Evaluate Human ABC Transporter ABCG2-Drug Interactions

Hikaru Saito, Hiroyuki Hirano, Hiroshi Nakagawa, Toshihisa Ishikawa

Session ID: 30PE-32
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_329_2

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TRANSPORTER-MEDIATED INFLUX AND EFFLUX MECHANISMS OF PITAVASTATIN, A NEW INHIBITOR OF HMG-CoA REDUCTASE

Shin-ichiro Ogawa, Tsuyoshi Saito, Junji Kojima, Hideki Fujino

Session ID: 30PE-33
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.330.1

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EFFECT OF CYCLOSPORIN A ON THE TRANSPORTER-MEDIATED HEPATIC UPTAKE AND BILIARY EXCRETION OF FEXOFENADINE IN MICE

Tomohiro Ubakai, Takuya Shiraishi, Yuko Kojima, Maki Shimizu, Kazuho O ...

Session ID: 30PE-34
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_330_2

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ESTIMATION OF IN VIVO KI VALUE OF FLUVOXAMINE AGAINST MELATONIN IN COMMON-METABOLISM BASED DRUG-DRUG INTERACTION BY DYNAMO-PK ANALYSIS METHOD

Katsumi Iga, Akiko Kiriyama, Akino Honbo

Session ID: 30PE-35
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.331.1

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INDUCTION OF UDP-GLUCURONOSYLTRANSFERASE AND SULFOTRANSFERASE IN PRIMARY CULTURES OF CRYOPRESERVED CYNOMOLGUS MONKEY AND HUMAN HEPATOCYTES

Masuhiro Nishimura, Akiko Koeda, Takefumi Shimizu, Yuichi Kawano, Mits ...

Session ID: 30PE-36
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_331_2

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INDUCTION OF NRF2-REGULATED ENZYMES BY NOTOPTERYGIUM RHIZOME EXTRACT PROTECTS AGAINST CELL DEATH ASSOCIATED WITH OXIDATIVE STRESS IN RAT LIVER CELLS

Tomokazu Ohnuma, Takao Komatsu, Takahito Nishiyama, Kenichiro Ogura, A ...

Session ID: 30PE-37
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.332.1

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Inhibition of the esterase activity in human and rodent hepatic microsomes by Grapefruit and Hyuganatsu

Masumi Imoto, Noriyuki Usami, Ikuo Yamamoto, Shinzo Hosoi, Akiyo Sakus ...

Session ID: 30PE-38
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_332_2

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OCCURRENCE FACTORS OF INFLUENZA-ASSOCIATED ACUTE ENCEPHALOPATHY INDUCED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. I

Masayuki Ohta, Maya Kazumi, Yasushi Miwa, Yoji Kitamura, Fumiyo Kasuya

Session ID: 30PE-39
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.333.1

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OCCURRENCE FACTORS OF INFLUENZA-ASSOCIATED ACUTE ENCEPHALOPATHY INDUCED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. II

Fumiyo Kasuya, Maya Kazumi, Masayuki Ohta, Yasushi Miwa, Kenji Tanaka, ...

Session ID: 30PE-40
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_333_2

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EFFECT OF D-GALACTOSAMINE/LIPOPOLYSACCHARIDE TREATMENT ON MITOCHONDRIAL GLUTATHIONE S-TRANSFERASE OF RATS

Kang Kwang Lee, Masataka Aniya, Shizuka Kinoshita, Sohel Hossain Quazi ...

Session ID: 30PE-41
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.334.1

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BUTYRYLCHOLINESTERASE AND ERYTHROCYTE ARYLESTERASE ARE RESPONSIBLE FOR GABEXATE HYDROLYSIS IN HUMAN BLOOD

Satoshi Yamaori, Mika Kushihara, Nobuhiro Fujiyama, Tatsuya Funahashi, ...

Session ID: 30PE-42
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_334_2

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CHARACTERIZATION OF RAT LIVER CARBOXYLESTERASE INVOLVED IN THE DEACETYLATION OF SPIRONOLACTONE

Fumika Okumura, Tomoki Kimura, Tomomichi Sone, Masakazu Isobe

Session ID: 30PE-43
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.335.1

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EVALUATION OF PHASE II METABOLISM AND BILIARY EXCRETION IN RAT LIVER SLICES

Kyoko Hirano, Yasuhisa Adachi, Shin-ichiro Nagatsuka, Shin-ichi Ninomi ...

Session ID: 30PE-44
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_335_2

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RENAL HANDLING OF CS-023 (RO4908463), A NOVEL PARENTERAL CARBAPENEM ANTIBIOTIC, IN RABBITS IN COMPARISON WITH MEROPENEM

Takahiro Shibayama, Naotoshi Yamamura, Yoko Matsushita, Daisuke Sugiya ...

Session ID: 30PE-45
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.336.1

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OATP1B1, OATP1B3 AND MRP2 ARE INVOLVED IN HEPATOBILIARY TRANSPORT OF OLMESARTAN, A NOVEL ANGIOTENSIN II BLOCKER

Rie Nakagomi, Daisuke Nakai, Yasushi Yoshigae, Kenji Kawai, Taro Tokui ...

Session ID: 30PE-46
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_336_2

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UNIQUE HUMAN PHARMACOKINETICS OF CS-023 (RO4908463), A NOVEL PARENTERAL CARBAPENEM ANTIBIOTIC, CAUSED BY TRANSPORTERS EXPRESSED IN HUMAN KIDNEY

Daisuke Sugiyama, Emi Kamiyama, Takahiro Shibayama, Naotoshi Yamamura, ...

Session ID: 30PE-47
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.337.1

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CHARACTERIZATION OF OATP-MEDIATED HEPATIC UPTAKE OF NAFCILLIN, A HIGH BILIARY EXCRETION TYPE OF BETA-LACTAM ANTIBIOTICS

Masanori Nakakariya, Takashi Iwanaga, Taiki Shimada, Hiroyuki Koibuchi ...

Session ID: 30PE-48
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_337_2

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DIFFERENTIAL CONTRIBUTION OF OATP TRANSPORTER SUBTYPES TO HEPATIC UPTAKE OF BETA-LACTAM ANTIBIOTICS IN RATS AND HUMANS

Taiki Shimada, Masanori Nakakariya, Hiroyuki Koibuchi, Takashi Iwanaga ...

Session ID: 30PE-49
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.338.1

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REGULATION OF LYSYL HYDROXYLASE 2 GENE EXPRESSION BY TRANSCRIPTION FACTOR MYB

Aya Shinoda, Kazuhiro Iguchi, Yukari Takahashi, Masafumi Kubota, Shige ...

Session ID: 30PE-50
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_338_2

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INVOLVEMENT OF NUCLEAR RECEPTOR PREGNANE X RECEPTOR (PXR) IN EXPRESSIONAL REGULATION OF ORGANIC CATION/CARNITINE TRANSPORTER OCTN2 (SLC22A5)

Miho Funabashi, Tomoji Maeda, Kiyoshi Nagata, Yasushi Yamazoe, Ikumi T ...

Session ID: 30PE-51
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.339.1

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CYCLOOXYGENASE-2 INDUCTION BY MDR1 INDUCERS IN CACO-2 CELLS

Misato Kokufu, Kazumasa Naruhashi, Kunihiko Morita

Session ID: 30PE-52
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_339_2

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INCREASE IN THE EXPRESSION OF MDR1 AND CYP3A4 BY SULPHONYL UREAS IN LS180 CELLS

Ryuhei Hayashi, Kohji Takara, Yuko Nakagawa, Yaeko Nango, Noriaki Kita ...

Session ID: 30PE-53
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.340.1

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REGULATION OF RENAL ORGANIC ANION TRANSPORTER EXPRESSIONS IN RAT KIDNEY ASSOCIATED WITH STREPTOZOTOCIN-INDUCED DIABETES MELLITUS

Maria Iwakiri, Takanobu Matsuzaki, Kanako Yoshitome, Hiroshi Watanabe, ...

Session ID: 30PE-54
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_340_2

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LIVER X RECEPTOR LIGANDS INDUCE THE EXPRESSION OF ATP-BINDING CASSETTE TRANSPORTER ABCC2 IN HUMAN HEPATOMA HEPG2 CELLS

Tatsuhiko Adachi, Hiroshi Nakagawa, Toshihisa Ishikawa

Session ID: 30PE-55
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.341.1

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ABCA AND ABCC TRANSPORTER mRNA EXPRESSION LEVELS AT THE MOUSE INNER BLOOD-RETINAL BARRIER

Ken-ichi Hosoya, Hidetoh Toki, Masatoshi Tomi, Masanori Tachikawa

Session ID: 30PE-56
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_341_2

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Effects of AhR ligands on IL-1beta expression caused by LPS

Rie Hara, Susumu Imaoka

Session ID: 30PE-57
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.342.1

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Example of Pharmacokinetic Simulations with PK-Sim^®: From Physico-Chemical Properties to Concentration Time Profiles

Hiroko Akiyama, Walter Schmitt, Stefan Willmann, Jörg Keldenich

Session ID: 30PE-58
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_342_2

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PREDICTION OF CLINICAL DIALYSIS CLEARANCE USING AN IN VITRO DIALYSIS SYSTEM

Shinichiro Sasago, Makoto Kono, Shinichi Fukuyama, Ayano Watanabe, Mas ...

Session ID: 30PE-59
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.343.1

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HUMAN UDP-GLUCURONOSYLTRANSFERASE, UGT1A8, GLUCURONIDATES DIHYDROTESTOSTERONE TO A MONOGLUCURONIDE AND FURTHER TO A STRUCTURALLY NOVEL DIGLUCURONIDE

Takahiro Murai, Naozumi Samata, Haruo Iwabuchi, Toshihiko Ikeda

Session ID: 30PE-60
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_343_2

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EVALUATION OF CONDITIONALLY IMMORTALIZED MOUSE BRAIN CAPILLARY ENDOTHELIAL CELLS AS IN VITRO BLOOD-BRAIN BARRIER MODEL BASED ON ABSOLUTE AMOUNT OF TRANSPORTER PROTEINS

Kazunari Yanai, Junichi Kamiie, Yuki Katsukura, Yumi Sekine, Satoshi U ...

Session ID: 30PE-61
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.344.1

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ACCUMULATION OF VECRONIUM-METABOLITE IN PATIENTS AFTER LIVING DONOR LIVER TRANSPLANTAION

Hiroaki Yamaguchi, Takanori Hishinuma, Kaori Suzuki, Masayoshi Saito, ...

Session ID: 30PE-62
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_344_2

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Inhibition of choline uptake transporter by gefitinib reduces phosphatidylcholine biosynthesis in primary cultured rat alveolar type II cells

Masanobu Oyabu, Naoki Ishiguro, Toshihiro Sato, Tomoji Maeda, Hironobu ...

Session ID: 30PE-63
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.345.1

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CONCENTRATION-DEPENDENT INTERACTION OF ANGIOTENSIN II RECEPTOR BLOCKERS WITH URIC ACID TRANSPORTERS IN KIDNEY AS CAUSES OF ALTERATION OF SERUM URIC ACID LEVEL

Masanobu Sato, Takashi Iwanaga, Hideaki Mamada, Toshio Ogihara, Tomoji ...

Session ID: 30PE-64
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_345_2

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NEW METABOLITES AND METABOLIC PATHWAY OF OXYBUTYNIN HYDROCHLORIDE

Terumi Watanabe, Minoru Ishikawa, Misa Ukon, Kaoru Takanaka, Koji Abe, ...

Session ID: 30PE-65
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.346.1

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HUMAN UGT1A1, 1A4, 1A6, AND 1A9 INTERACT WITH EACH OTHER TO AFFECT ENZYMATIC ACTIVITIS

Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh, Shin-i ...

Session ID: 30PE-66
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_346_2

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UGT-UGT INTERACTION AFFECTS ENZYMATIC ACTIVITY: STEREOSELECTIVE FORMATION OF 5-(4'-HYDROXYPHENYL)-5-PHENYLHYDANTOIN GLUCURONIDE BY HUMAN UGT1A1, 1A9 AND 2B15

Hiroyuki Yamanaka, Miki Nakajima, Ryoichi Fujiwara, Miki Katoh, Tsuyos ...

Session ID: 30PE-67
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.347.1

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METABOLIC PROFILE OF FYX-051 (4-(5-PYRIDIN-4-YL-1H-[1,2,4]TRIAZOL-3-YL)PYRIDINE-2- CARBONITRILE) IN THE RAT, DOG, MONKEY, AND HUMAN

Takashi Nakazawa, Kengo Miyata, Koichi Omura, Takashi Iwanaga, Osamu N ...

Session ID: 30PE-68
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_347_2

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INDIVIDUAL DIFFERENCES OF FLAVIN-CONTAINING MONOOXYGENASE 3 (FMO3) IN HUMAN LIVER MICROSOMES

Hiroshi Yano, Makiko Shimizu, Norie Murayama, Hiroshi Yamazaki

Session ID: 30PE-69
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.348.1

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STRAIN DIFFERENCE ANALYSIS OF RAT LIVER ALDEHYDE OXIDASE ACTIVITY

Hiroaki Maruyama, Kouichi Hoshino, Kunio Itoh, Yorihisa Tanaka

Session ID: 30PE-70
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_348_2

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ANALYSIS OF THE FUNCTION OF MONKEY LIVER ALDEHYDE OXIDASE

Tasuku Asakawa, Kouichi Hoshino, Mayuko Adachi, Akiko Masubuchi, Toshi ...

Session ID: 30PE-71
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.349.1

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