Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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25th JSSX Annual meeting

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Oral Presentations 26. Transporter - 5

RIBAVIRIN UPTAKE SYSTEMS ARE REQUIRED FOR THE ANTI-HEPATITIS C VIRUS ACTIVITY

Minami Iikura, Tomomi Furihata, Masanori Ikeda, Nobuyuki Kto, Kan Chib ...

Session ID: 3-E-10-5
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.151.0

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Poster Presentations - 1

QUANTITATIVE PREDICTION OF THE HUMAN INTESTINAL AVAILABILITY OF NIFEDIPINE

Satoshi Yoshikawa, Tomoo Itoh

Session ID: 1-P-01
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.152.0

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EFFECT OF CYP3A INDUCTION BY EFAVIRENZ ON INTESTINAL AND HEPATIC METABOLISM OF TRIAZOLAM

Taku Kasai, Harumi Yamada, Iori Hirosawa, Yasunari Mano, Masataka Taji ...

Session ID: 1-P-02
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.153.0

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PREDICTION OF THE INTESTINAL FIRST-PASS METABOLISM OF CYP3A SUBSTRATES IN HUMANS USING CYNOMOLGUS MONKEYS

Haruka Nishimuta, Kimihiko Sato, Masashi Yabuki, Setsuko Komuro

Session ID: 1-P-03
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.154.0

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DEVELOPMENT OF QUANTITATIVE HUMAN ABSORPTION PREDICTION SYSTEM IN DRUG DISCOVERY (1) -SUPERSATURATION AND MAXIMUM ABSORBABLE DOSE OF POORLY-SOLUBLE DRUGS-

Shunsuke Ozaki, Hiroko Shinjo, Susumu Takakuwa, Takashi Kato

Session ID: 1-P-04
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.155.0

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DEVELOPMENT OF QUANTITATIVE HUMAN ABSORPTION PREDICTION SYSTEM IN DRUG DISCOVERY (2) -SEPARATE EVALUATION OF PASSIVE PERMEABILITY FOR PRECISE PREDICTION OF INTESTINAL ABSORPTION INCLUDING THE ROLE OF EFFLUX TRANSPORT-

Hiroko Shinjo, Shunsuke Ozaki, Susumu Takakuwa, Takashi Kato

Session ID: 1-P-05
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.156.0

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DEVELOPMENT OF QUANTITATIVE HUMAN ABSORPTION PREDICTION SYSTEM IN DRUG DISCOVERY (3) -PHYSICOCHEMICAL PROPERTY ORIENTED AND PHYSIOLOGICALLY BASED ABSORPTION SIMULATION PERFORMED WITH GASTROPLUS-

Susumu Takakuwa, Hiroko Shinjo, Shunsuke Ozaki, Takashi Kato

Session ID: 1-P-06
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.157.0

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OATPS-INHIBITED EFFECTS OF RIFAMPICIN ON THE PHARMACOKINETICS OF FEXOFENADINE ENANTIOMERS

Yumiko Akamine, Masatomo Miura, Norio Yasui-Furukori, Tsukasa Uno

Session ID: 1-P-07
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.158.0

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TRANSPORT MECHANISM OF CARNITNE IN MOUSE PRIMARY CULTURED CEREBROCORTICAL NEURONS

Kai Ohashi, Mikio Kakumoto, Tomonobu Okano, Yuka Moriya, Takuya Fujita

Session ID: 1-P-08
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.159.0

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FUNCTIONAL CHARACTERIZATION OF Na+-DEPENDENT ASCORBATE TRANSPORTER (SVCT2) IN HUMAN ASTROCYTES

Motoki Ebata, Mikio Kakumoto, Tomonobu Okano, Yuka Moriya, Takuya Fuji ...

Session ID: 1-P-09
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.160.0

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COMPARISON BETWEEN IN VITRO BIDIRECTIONAL PERMEABILITY STUDY FOR HUMAN MDR1 AND IN VIVO RAT CENTRAL NERVOUS SYSTEM PENETRATION TO INVESTIGATE SPECIES DIFFERENCE

Katsumasa Otake, Izumi Iida, Hidetou Toki, Hana Sasaki, Yasunori Kawak ...

Session ID: 1-P-10
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.161.0

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TRANSPORT CHARACTERISTICS OF N-ACETYL-L-ASPARTYL-L-GLUTAMATE (NAAG) IN MOUSE PRIMARY CULTURED CEREBROCORTICAL ASTROCYTES

Yuto Ishihara, Mikio Kakumoto, Tomonobu Okano, Yuka Moriya, Takuya Fuj ...

Session ID: 1-P-12
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.163.0

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DRUG TRANSPORT ACROSS THE BLOOD-RETINAL BARRIER

Ken-ichi Hosoya, Atsushi Yamamoto, Shin-ichi Akanuma, Masanori Tachika ...

Session ID: 1-P-13
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.164.0

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TRANSPORT OF URIC ACID ACROSS BRAIN BARRIER SYSTEM

Sayaka KATO, Takashi OKURA, Yoshiharu DEGUCHI

Session ID: 1-P-14
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.165.0

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NMQ IS A USEFUL FLUORESCENT PROBE FOR EVALUATING MDR1 BY VESICULAR TRANSPORT ASSAY

Masa Yasunaga, Kenji Tanaka, Miyako Maeda, Shigeki Enomoto, Yoshiaki H ...

Session ID: 1-P-15
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.166.0

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DIFFERENTIAL EXPRESSION OF COPPER EFFLUX AND INFLUX TRANSPORTERS IN RAT DRG TISSUE MAY INFLUENCE OXALIPLATIN NEUROTOXICITY

Virginia Ip, Johnson Liu, Julian Mercer, Mark McKeage

Session ID: 1-P-16
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.167.0

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CHARACTERIZATION OF THE HUMAN OCT1-MEDIATED TRANSPORT OF DAPI AS A FLUORESCENT PROBE SUBSTRATE

Tomoya Yasujima, Kin-ya Ohta, Katsuhisa Inoue, Hiroaki Yuasa

Session ID: 1-P-17
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.168.0

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FUNCTIONAL EXPRESSION OF CARNITINE/ORGANIC CATION TRANSPORTER OCTN1 (SLC22A4) IN MOUSE BRAIN

Takayuki Taguchi, Noritaka Nakamichi, Tomoko Sugiura, Tomohiko Wakayam ...

Session ID: 1-P-18
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.169.0

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ESTIMATION OF TRANSPORTERS INVOLVED IN HEPATOBILIARY TRANSPORT USING SANDWICH-CULTURED HEPATOCYTES ON OXYGEN-PERMEABLE MEMBRANES

Hitoshi Matsui, Ken-ichi Kaneko, Tomoharu Osada, Masaru Sekijima, Yosh ...

Session ID: 1-P-19
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.170.0

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UBIQUITIN-DEPENDENT DEGRADATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN ENDOSOMAL-LYSOSOMAL PATHWAY

Tadahaya Mizuno, Hisamitsu Hayashi, Yuichi Sugiyama

Session ID: 1-P-20
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.171.0

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A NOVEL mRNA SPLICING ISOFORM IS A REAL CANCER-TYPE ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3 mRNA

Seiya Ishii, Tomomi Furihata, Miki Nagai, Sayaka Matsumoto, Kan Chiba

Session ID: 1-P-21
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.172.0

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ALTERATION OF ORGANIC ANION TRANSPORTING POLYPEPTIDES AFTER INTESTINAL ISCHEMIA-REPERFUSION

Jiro Ogura, Hajime Maruyama, Masaki Kobayashi, Shirou Itagaki, Hiroaki ...

Session ID: 1-P-22
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.173.0

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MECHANISM OF EXTRA-RENAL EXCRETION OF URIC ACID IN RATS

Atsushi Hosomi, Takeo Nakanishi, Ikumi Tamai

Session ID: 1-P-23
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.174.0

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INTERACTION BETWEEN GUANIDINO COMPOUNDS AND HUMAN MULTIDRUG AND TOXIN EXTRUSION (hMATE)1 AND hMATE2-K

Shin-ya Motoyama, Satohiro Masuda, Tomoko Sato, Toshiya Katsura, Ken-i ...

Session ID: 1-P-24
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.175.0

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QUANTITATIVE VISUALIZATION FOR BILE CANALICULAR TRANSPORTER FUNCTION USING SANDWICH-CULTURED RAT HEPATOCYTES

Yoko Fukuyama, Takeo Nakanishi, Miho Ikenaga, Yoshiyuki Shirasaka, Iku ...

Session ID: 1-P-25
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.176.0

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PREDICTION OF ABSORPTION RATE FROM THE LIVER SURFACE IN THE PRESENCE OF VISCOUS ADDITIVES BY IN VITRO RELEASE EXPERIMENT USING SEMI-PERMEABLE MEMBRANE

Koyo Nishida, Ryosuke Sato, Kazumi Wakasugi, Rei Tomonaga, Satomi Kond ...

Session ID: 1-P-26
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.177.0

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IMPROVED DISSOLUTION AND PHARMACOKINETIC BEHAVIOR OF CYCLOSPORINE A USING HIGH-ENERGY AMORPHOUS SOLID DISPERSION APPROACH

Satomi Onoue, Hideyuki Sato, Kumiko Ogawa, Yohei Kawabata, Takahiro Mi ...

Session ID: 1-P-27
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.178.0

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THE DEVELOPMENT OF TRANSDERMAL ARTIFICIAL PANCREAS ISLET

Ayami Inaba, Daisuke Shibata, Naruyoshi Fujiwara, Makoto Haga

Session ID: 1-P-28
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.179.0

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DEVELOPMENT OF A NEW MICROEMULSION FORMULATION OF CYCLOSPORINE (CsA) INCLUDING A BIOAVAILABILITY ENHANCER, ETHYL DOCOSAHEXAENOATE (DHA-EE), AS AN OIL EXCIPIENT

Vilasinee Hirunpanich Sato, Erika Sugiyama, Kiyomi Saito, Hitoshi Sato

Session ID: 1-P-29
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.180.0

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RAPID SCREENING FOR DIRECT AND TIME-DEPENDENT INHIBITIONS OF 8 CYTOCHROME P450 ISOFORMS WITH A COCKTAIL OF 9 PROBE SUBSTRATES AND A SINGLE RUN OF UPLC-MS/MS

Yasuhiro Yamada, Kazumasa Kozakai, Motoji Oshikata, Taiji Kawase, Yuka ...

Session ID: 1-P-30
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.181.0

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SUCCESSFUL APPLICATION FOR PREDICTION OF IN VIVO DRUG-DRUG INTERACTION FROM OBTAINED IN VITRO INHIBITION PARAMETERS USING A COCKTAIL-SUBSTRATE APPROACH

Kazumasa Kozakai, Yasuhiro Yamada, Motoji Oshikata, Taiji Kawase, Yuka ...

Session ID: 1-P-31
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.182.0

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USE OF IN VIVO SPECT IMAGING TO ASSESS PENETRATION OF A HUMANIZED ANTI-GPC3 MONOCLONAL ANTIBODY (GC33) INTO TUMOUR TISSUES IN XENOGRAFT MICE

Jun Amano, Yasuhiro Magata, Yasuko Matsumoto, Yasuko Kinoshita, Genki ...

Session ID: 1-P-32
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.183.0

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HUMANIZED ANTI-GPC3 ANTIBODY (GC33) EXHIBITED NONLINEAR PHARMACOKINETICS AND TUMOR-SPECIFIC BIODISTRIBUTION IN A PRE-CLINICAL STUDY

Genki Nakamura, Jun Amano, Akihisa Kaneko, Azusa Yoshino, Kohnosuke Na ...

Session ID: 1-P-33
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.184.0

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HIGHLY SIGNIFICANT CYP ACTIVITIES OF HEPATOCYTE-LIKE CELLS DIFFERENTIATED FROM HUMAN ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS

Shin Enosawa, Yasuhiro Yamada, Hisae Takatsu, Satoshi Suzuki, Takahiro ...

Session ID: 1-P-34
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.185.0

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MODIFICATION OF INDUCIBLE CYP1A1 EXPRESSION IN THE PRESENCE OF FLAVONOIDS

Nobuo Nemoto, Sachiko Kondo, Waranya Chatuphonprasert, Kanokwan Jaruka ...

Session ID: 1-P-35
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.186.0

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IDENTIFICATION AND ANALYSIS OF CYP1D1 IN CYNOMOLGUS MONKEY

Yasuhiro Uno, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki

Session ID: 1-P-36
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.187.0

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DIFFERENCE IN REGIOSELECTIVE OXIDATION OF BUFURALOL BETWEEN MARMOSET CYP2D19 AND HUMAN CYP2D6

Shizuo Narimatsu, Toshiyuki Nakata, Kazufumi Masuda, Takashi Katsu, Sh ...

Session ID: 1-P-37
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.188.0

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FUNCTIONAL CHARACTERIZATION OF CYP2C8.13 AND CYP2C8.14

CATALYTIC ACTIVITIES TOWARD PACLITAXEL AND AMIODARONE

Nobumitsu Hanioka, Kimiaki Matsumoto, Yoshiro Saito, Shizuo Narimatsu

Session ID: 1-P-38
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.189.0

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SPECIES DIFFERENCE BETWEEN CYNOMOLGUS MONKEY AND HUMAN ON P450-DEPENDENT DRUG OXIDATIONS IN LIVER MICROSOMES

Chie Emoto, Kazuhide Iwasaki, Ryo Koizumi, Masahiro Utoh, Norie Muraya ...

Session ID: 1-P-39
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.190.0

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PREDICTION OF REGIOSELECTIVITY AND ORDER OF THE OCCURRENCE FOR CYP-MEDIATED REACTION

Kazumi Ito, Yoshiya Yamamura, Kouichi Yoshinari, Yasushi Yamazoe

Session ID: 1-P-40
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.191.0

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METABOLISM OF NICOTINE IN RAT LUNG MICROVASCULAR ENDOTHELIAL CELLS

Eiichi Sakurai, Eiko Sakurai, Yukari Ueda, Yasuyuki Yagi

Session ID: 1-P-41
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.192.0

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Effect of oxidative stress on the pharmacokinetics of atazanavir

Hiroaki Aoyama, Sinji Kobuchi, Tatsuma Matsuda, Yukako Ito, Nobuyuki S ...

Session ID: 1-P-42
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.193.0

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THE COMPARISON OF NON-CYP ENZYME ACTIVITY BETWEEN FRESH AND CRYOPRESERVED HEPATOCYTES

Takafumi Akabane, Nicoals Gerst, Jeffrey Masters, Kouichi Tamura

Session ID: 1-P-43
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.194.0

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DIFFERENCE IN PHENACETIN AND ACETAMINOPHEN TOXICITIES IS DUE TO SUBSTRATE SPECIFICITY OF HUMAN ARYLACETAMIDE DEACETYLASE

Tatsuki Fukami, Akinobu Watanabe, Shiori Takahashi, Yuki Kobayashi, Na ...

Session ID: 1-P-44
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.195.0

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BONITOS AS PALLIATIVE CARE FOR JAPANESE TRIMETHYLAMINURIA SUBJECTS

Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki

Session ID: 1-P-45
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.196.0

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IN VIVO AND IN VITRO METABOLISM OF IBUPROFEN IN HUMAN-CHIMERIC MICE

Aya Horiguchi, Seigo Sanoh, Kazumi Sugihara, Chise Tateno, Toru Horie, ...

Session ID: 1-P-46
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.197.0

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IN VITRO-IN VIVO RELATIONSHIP OF SMALL INTESTINAL GLUCURONIDATION IN MONKEYS

Hiroyuki Moriguchi, Fumihiro Nakamori, Yoichi Naritomi, Katsuhiro Yama ...

Session ID: 1-P-47
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.198.0

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IN VITRO-IN VIVO RELATIONSHIP OF SMALL INTESTINAL GLUCURONIDATION IN RATS

Kazuhiro Tetsuka, Takako Furukawa, Fumihiro Nakamori, Katsuhiro Yamano ...

Session ID: 1-P-48
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.199.0

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COMPARISON OF CATALYTIC PROPERTIES BETWEEN HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A7*3, AN ALLELIC VARIANT, AND ITS WILD-TYPE 1A7*1

Hiroki Koba, Yuji Ishii, Toshiya Oizaki, Nurrochmad Arief, Shin-ichi I ...

Session ID: 1-P-49
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.200.0

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QUANTITATIVE PREDICTION OF GLUCURONIDATION IN HUMAN LIVER AND SMALL INTESTINE

Fumihiro Nakamori, Yoichi Naritomi, Hiroyuki Moriguchi, Katsuhiro Yama ...

Session ID: 1-P-50
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.201.0

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