Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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25th JSSX Annual meeting

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Poster Presentations - 1

MODULATION OF CYTOCHROME P450 ACTIVITY BY UDP-GLUCURONOSYLTRANSFERASE: MAJOR HUMAN UGT ISOFORMS, UGT2B7, 1A1, 1A6 AND 1A9 ENHANCE CYP3A4-CATALYZED OXIDATION

Yuu Miyauchi, Yuji Ishii, Hideyuki Yamada

Session ID: 1-P-51
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.202.0

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Assessment of Reactivity of Acylglucuronide at Early Stage of Drug Discovery

Kazuko Inoue, Tomoki Nishioka, Katsuyuki Fukuda, Kazutomi Kusano, Tsut ...

Session ID: 1-P-52
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.203.0

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StRUCTURE-FUNCTION RELATIONSHIPS OF THE INHIBITION OF HUMAN CYTOCHROMES P450 1A1. 1A2, 1B1, 2C9, AND 3A4 BY 33 FLAVONOID DERIVATIVES

Tsutomu Shimada, Katsuhiro Tanaka, Shigeo Takenaka, Norie Murayama, Ma ...

Session ID: 1-P-53
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.204.0

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THE SMALL-MOLECULE TYROSINE KINASE INHIBITOR NILOTINIB IS A POTENT NONCOMPETITIVE INHIBITOR OF THE SN-38 GLUCURONIDATION BY HUMAN UGT1A1

Minako Sugiyama, Ken-ichi Fujita, Yuko Akiyama, Yu Sunakawa, Hiroo Ish ...

Session ID: 1-P-54
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.205.0

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PRECLINICAL AND CLINICAL ASSESSMENTS OF RENAL TRANSPORTER-MEDIATED DRUG INTERACTION OF VARENICLINE, A THERAPY FOR SMOKING CESSATION

Yasuhiro Yamato, Bo Feng, Ronald Obach, Helene Faessel

Session ID: 1-P-55
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.206.0

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INHIBITORY EFFECTS OF MAJOR CANNABINOIDS ON HUMAN CYP2A6 AND CYP2B6 ACTIVITIES

Chikako Maeda, Satoshi Yamaori, Ikuo Yamamoto, Kazuhito Watanabe

Session ID: 1-P-56
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.207.0

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STRUCTURAL REQUIREMENT FOR INHIBITORY EFFECT OF CANNABIDIOL ON CYP1A1 ACTIVITY

Yoshimi Okushima, Satoshi Yamaori, Kazufumi Masuda, Shizuo Narimatsu, ...

Session ID: 1-P-57
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.208.0

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Direct inhibition of human CYP3A enzymes by cannabidiol

Satoshi Yamaori, Juri Ebisawa, Yoshimi Okushima, Ikuo Yamamoto, Kazuhi ...

Session ID: 1-P-58
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.209.0

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Inhibition of CYP3A activity by ritonavir

Motoyasu Kanamori, Tomoo Itoh

Session ID: 1-P-59
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.210.0

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CROSSTALK OF MAIN CYTOCHROME P450 ISOZYME FOR METABOLISM-DEPENDENT INHIBITION

Syoko Inatani, Hirotoshi Okumura, Yasuhiro Nakai, Hidetoshi Urano

Session ID: 1-P-60
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.211.0

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INVOLVEMENT OF MITOCHONDRIAL MEMBRANE-BOUND GLUTATHIONE TRANSFERASE IN ACETAMINOPHEN-INDUCED HEPATOTOXICITY

Ryosuke katayama, Naoki Imaizumi, Yoko Aniya

Session ID: 1-P-61
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.212.0

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ROLES OF GLUTAMATE-CYSTEINE LIGASE AND MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4 IN GENDER-DEPENDENT SUSCEPTIBILITY TO ACETAMINOPHEN HEPATOTOXICITY

Yasuhiro Masubuchi, Yasuko Watanabe

Session ID: 1-P-62
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.213.0

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THE ROLE OF NRF2 ON MULTIDRUG RESISTANCE

Masahiro Ono, Shuichi Sekine, Toshiharu Horie

Session ID: 1-P-63
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.214.0

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THE UREMIC SOLUTE INDOXYL SULFATE ACTS AS A NOVEL ENDOGENOUS ANTIOXIDANT AGAINST SUPEROXIDE ANION RADICALS

Hiroshi Watanabe, Yohei Miyamoto, Yasunori Iwao, Yuka Tasaki, Keizo Sa ...

Session ID: 1-P-64
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.215.0

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CELL-BASED SCREENING OF INDUSTRIAL CHEMICAL COMPOUNDS FOR THE ACTIVATION OF PREGNANE X RECEPTOR AND CONSTITUTIVE ANDROSTANE RECEPTOR

Jun Imai, Kouichi Yoshinari, Yasushi Yamazoe

Session ID: 1-P-65
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.216.0

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A NOVEL MECHANISM OF INTESTINAL INDUCTION OF MDR1 GENE BY RIFAMPICIN

Kaoru Kobayashi, Naoya Kameyama, Shoko Shimizu, Yuki Yamasaki, Mika En ...

Session ID: 1-P-66
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.217.0

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MICRORNAS POST-TRANSCRIPTIONALLY REGULATE DIHYDROPYRIMIDINE DEHYDROGENASE GENE EXPRESSION

Takeshi Hirota, Hiroshi Takane, Kenji Otsubo, Ichiro Ieiri

Session ID: 1-P-67
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.218.0

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A role of miR-122 in the phenobarbital-regulated gene expression

Ryota Shizu, Chiharu Murakami, Satoshi Numazawa, Takemi Yoshida

Session ID: 1-P-68
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.219.0

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ENTEROBACTERIA MODULATE INTESTINAL BILE ACID ABSORPTION THROUGH REGULATION OF ILEAL ASBT EXPRESSION

Hiroki Yamakawa, Masaaki Miyata, Hideaki Kuribayashi, Yuki Takamatsu, ...

Session ID: 1-P-69
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.220.0

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ROLE OF CHROMATIN STRUCTURE AND HEPATOCYTE NUCLEAR FACTOR 4 ALPHA IN THE REGULATION OF CYP3A41 GENE EXPRESSION IN FEMALE MOUSE LIVER

REGULATION OF FEMALE-SPECIFIC CYP3A41 GENE

Tsutomu Sakuma, Satomi Ikematsu, Wattanaporn Bhadhprasit, Yuki Kawasak ...

Session ID: 1-P-70
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.221.0

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TRANSACTIVATION OF HUMAN CYP1A1 AND CYP1A2 BY NUCLEAR RECEPTOR LXR ARUFA

Kikuko Araki, Kouichi Yoshinari, Noriaki Yoda, Naoya Tani, Yasushi Yam ...

Session ID: 1-P-71
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.222.0

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EXPRESSION OF UGT1A1 IS REGULATED BY CELL SIGNALS LINKED TO CELL-CYCLE PROGRESSION

Masatoshi Kurosawa, Takahiro Uchida, Akira Ikari, Masao Miwa, Junko Su ...

Session ID: 1-P-72
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.223.0

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SIMULATION OF DRUG INTERACTION OF MIDAZOLAM WITH TRIAZOLE ANTIFUNGAL AGENTS BY DYNAMO-PK ANALYSIS METHOD

Katsumi Iga, Akiko Kiriyama, Akino Honbo

Session ID: 1-P-73
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.224.0

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THE BUILDING OF CEFTRIAXONE (CTRX) MODEL FOR TIME-DEPENDENT CEREBROSPINAL FLUID (CSF) TRANSFER

Tomohisa Saito, Satofumi Iida, Hidenobu Aso, Takehiko Kawanishi

Session ID: 1-P-74
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.225.0

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DIFFERENTIATION OF MONKEY EMBRYONIC STEM CELLS TO HEPATOCYTES AND PHARMACOKINETIC STUDIES

Junya Maruyama, Sakae Sakamoto, Tamihide Matsunaga, Katsunori Nakamura ...

Session ID: 1-P-75
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.226.0

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PHARMACOKINETIC ANALYSIS OF HEPATIC EXTRACTION OF MODEL COMPOUNDS FOR PREDICTION OF DRUG DISPOSITION UNDER VARIOUS BODY TEMPERATURES

Hirotaka Miyamoto, Kotaro Komori, Satoshi Matsueda, Keiko Abe, Shintar ...

Session ID: 1-P-76
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.227.0

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COMPARATIVE ASSESSMENT FOR PREDICTION OF HUMAN PHARMACOKINETICS USING PHYSIOLOGICAL AND EMPIRICAL APPROACHES

STRATEGY OF HUMAN PHARMACOKINETICS PREDICTION

Hiroyuki Sayama, Hiroshi Komura, Motohiro Kogayu

Session ID: 1-P-77
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.228.0

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EFFECT OF UREMIC TOXINS ON THE PHARMACOKINETICS OF IMATINIB IN RENAL FAILURE

Takashi Uchida, Yuji Yamakawa, Hiroki Kamobayashi, Akinobu Hamada, Hid ...

Session ID: 1-P-78
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.229.0

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ASSOCIATION OF GENETIC POLYMORPHISMS OF ORM1 AND ORM2 WITH PLASMA LEVEL OF ALPHA-1-ACID GLYCOPROTEIN IN JAPANESE CANCER PATIENTS

Noriko Katori, Kimie Sai, Yoshiro Saito, Hiromi Fukushima-Uesaka, Koui ...

Session ID: 1-P-79
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.230.0

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CONSTRUCTION OF REFERENCE RECOMBINANT PROTEIN FOR VALIDATING ABSOLUTE QUANTIFICATION BY MULTIPLEXED-MRM ANALYSIS

Yusuke Tomioka, katsuaki Ito, Sumio Ohtsuki, Junichi Kamiie, Tetsuya T ...

Session ID: 1-P-80
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.231.0

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THE EXAMINATION ON DIVERSITY OF DECISION USING THE GOODNESS-OF-FIT PLOTS FOR POPULATION PHARMACOKINETIC ANALYSIS

Yuka Kokaji, Ishida Yoshimasa, Takahiko Aoyama, Megumi Kurokawa, Hiden ...

Session ID: 1-P-81
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.232.0

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EVALUATION OF PLASMA RENIN ACTIVITY-BASED PK-PD MODEL FOR HYPOTENSIVE EFFECT AFTER COADMINISTRATION OF LOSARTAN AND HYDROCHLOROTHAIZIDE

Ryosuke Shimizu, Makoto Miyazaki, Kazunori Iwanaga, Masawo Kakemi

Session ID: 1-P-82
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.233.0

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INTRAPULMONARY PHARMACOKINETIC AND PHARMACODYNAMIC ASSESSMENT OF AUC/MIC OF MACROLIDE ANTIMICROBIAL AGENTS FOR OPTIMIZING THE TREATMENT OF RESPIRATORY INFECTIONS

Makoto Miyazaki, Kohei Togami, Sumio Chono, Kazuhiro Morimoto, Masawo ...

Session ID: 1-P-83
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.234.0

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GROUPING OF NEPHROTOXIC CHEMICALS BASED ON TOXICOLOGICAL MECHANISMS

HuiQi Zhang, Takashi Yamada, Yushiro Tanaka, Jun Yamada, Makoto Hayash ...

Session ID: 1-P-84
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.235.0

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QSAR CLASSIFICATION BETWEEN HEPATICALLY- AND RENALLY-ELIMINATED DRUGS USING A MACHINE LEARNING TECHNIQUE

Yoshihiro Uesawa, Harumi Takahashi, Hiroyasu Ogata, Kiminori Mohri

Session ID: 1-P-85
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.236.0

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SITES OF METABOLIC SUBSTITUTION: DEFINITIVE METABOLITE STRUCTURES DEDUCED USING ION MOBILITY AND MOLECULAR MODELING

Iain Campuzano, Gordon Dear, Jordi Munoz-Muriedas, Jayne Kirk, Motoji ...

Session ID: 1-P-86
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.237.0

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A QUESTIONNAIRE SURVEY ON NONCLINICAL SAFETY EVALUATION OF DRUG METABOLITES

Toshiya Minagawa, Kosuke Kawashima, Koji Takekawa, Kouichi Minato, Tak ...

Session ID: 1-P-87
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.238.0

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HIGH QUIALITY LC/MS ANALYTICAL METHODS DATABASE FOR EARLY-STAGE-DRUG DISCOVERY

Miho Ayabe, Shigeru Yamada, Ryoma Yamamoto, Yasutoshi Kawase, Shinichi ...

Session ID: 1-P-88
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.239.0

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ANALYTICAL CHALLENGES IN THE DEVELOPMENT OF A QUANTITATIVE SPE/LC/MS/MS ASSAY FOR AMYLOID BETA PEPTIDES IN CEREBROSPINAL FLUID

Sasaki Shunya, Erin Chambers, Mary Lame, Diane Diehl, Sarah Grimwood, ...

Session ID: 1-P-89
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.240.0

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COMPARISON OF ACCURATE MASS AND NOMINAL MASS MSMS FOR THE SIMULTANEOUS ACQUISITION OF QUALITATIVE AND QUANTITATIVE DATA IN DMPK STUDIES

Joanne Mather, Marian Twohig, Paul Rainville, Ronan O'malley, Motoji O ...

Session ID: 1-P-90
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.241.0

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APPLICATION OF LOW BACKGROUND LIQUID SCINTILLATION COUNTING METHOD TO PHARMACY:

IV. FUNDAMENTAL STUDY ON MEASUREMENT OF CARBON-14 RADIOACTIVITY IN PLASMA

Masanobu Horie, Shigeo Baba, Yuka Kato, Tomoyuki Yoshimura

Session ID: 1-P-91
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.242.0

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Poster Presentations - 2

DIFFERENTIAL INTERACTION OF FRUIT JUICES ON TRANSPORTER-MEDIATED ABSORPTION OF DRUGS

Megumi Shichiri, Yoshiyuki Shirasaka, Takanori Mori, Takeo Nakanishi, ...

Session ID: 2-P-01
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.243.0

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USEFULNESS OF ACYLCARNITINES AS SAFE AND EFFICIENT INTESTINAL ABSORPTION ENHANCERS

Nobuyuki Doi, Aoi Kimura, Mikio Tomita, Masahiro Hayashi

Session ID: 2-P-02
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.244.0

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EFFECTS OF AMINOGUANIDINE ON INTESTINAL ISCHEMIA/REPERFUSION INJURY

Takuya Kitazato, Yusuke Takizawa, Yasuhiko Ito, Naomi Kamiya, Haruka I ...

Session ID: 2-P-03
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.245.0

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A NEW CALCULATION METHOD OF INTESTINAL AVAILABILITY

Ayako Tsukihashi, Akihiro Hisaka, Hiroshi Suzuki

Session ID: 2-P-04
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.246.0

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REMODELING OF INTESTINAL EPITHELIAL CELLS BASED ON EXPRESSION LEVELS OF CLAUDIN FAMILY

Tomomi Aoki, Kyohei Hirano, Kazuhiko Takahata, Mikio Tomita, Masahiro ...

Session ID: 2-P-05
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.247.0

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EFFECTS OF SODIUM NITROPRUSSIDE ON MUCOSAL MEMBRANE IN RAT SMALL INTESTINE

Yusuke Takizawa, Takuya Kitazato, Yasuhiko Ito, Haruka Ishizaka, Naomi ...

Session ID: 2-P-06
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.248.0

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EFFECTS OF FENUGREEK SEED EXTRACT ON THE ABSORPTION OF CHORESTEROL IN RATS

Hong Sui, Nobuhiro Nishimura, Akira Yamamoto, Hideki Okunishi, Kohji N ...

Session ID: 2-P-07
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.249.0

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MODULATED TISSUE DISTRIBUTION AND INCREASED INTESTINAL TOXICITY OF METHOTREXATE UNDER HYPERBILIRUBINEMIA IN RATS

Tomoharu Yokooji, Nobuhiro Mori, Teruo Murakami

Session ID: 2-P-08
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.250.0

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STUDY ON A REGULATING SITE IN A PH-DEPENDENT DIPEPTIDE TRANSPORT BY PEPT1

Seiji Miyauchi, Yuki Fujisawa, Toshifumi Nara, Naoki Kamo

Session ID: 2-P-09
Published: 2010
Released on J-STAGE: December 15, 2010

DOIhttps://doi.org/10.14896/jssxmeeting.25.0.251.0

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