Objectives: The effect of statin on the inflammatory response and postoperative course after endovascular abdominal aortic repair (EVAR) was investigated.
Methods: During April 2008 and March 2012, 151 abdominal aortic aneurysm patients underwent EVAR in our hospital. Among these 151 patients, 66 patients did not take any kinds of statin. For 32 patients, strong statin was prescribed and other type of statin was prescribed for 11 patients. The postoperative body temperature, white blood cell count (WBC), serum C-reactive protein (CRP, mg/dl), postoperative hospital stay period and postoperative complications after EVAR were compared among 3 groups.
Results: The period of maximal body temperature higher than 37.5 degree or 38.0 degree did not differ among 3 groups. The WBC on the postoperative day (POD) 1, 3 and 6 did not differ among 3 groups. The CRP on POD 1 and 3 were significantly lower in the strong statin group than no statin group (POD 1: strong statin group 2.5 ± 1.4, no statin group 4.1 ± 1.9, p=0.0002, POD 3: strong statin group 8.2 ± 3.1, no statin group 10.5 ± 4.4, p=0.039). There was no significant difference between no statin group and other type statin group on POD 1, 3. In the no statin group, postoperative stay period prolonged in 6 patients because of postoperative complications, however no postoperative complication occurred in the statin groups.
Conclusion: Strong statin attenuated postoperative inflammatory reaction early after EVAR procedure and statin might prevent postoperative complication. These effect of statin depend on the intensity of statin.
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