The aim of study was to clarify whether atherosclerotic plaque morphology, as defined by ultrasound image, was related to the cerebral ischemic change. We performed the ultrasonography using SONOS 5500 (Phillips Co Ltd, USA) in 297 subjects who were 139patients with hypertension at Hypertension Center of Kinki Central Hospital and 158subjects taking of cerebral health screening examination at the Health Care Center of Kinki Central Hospital. The presence of atherosclerotic plaque was analyzed histological changes using integrated backscatter echo signals by acoustic densitometry method and subjects and patients were divided into 4 groups: subjects or patients without atherosclerotic plaque (N group), those with soft plaque only (S group), those with soft plaque including low density core (I., group) and those with hard plaque (H group). Cerebral ischemic changes observed by MRI were shown at a significant higher rate in L group (71.9%) and H group (61.3%) than N group (24.2%) and S group (30.4%). The parameters showing atherosclerotic changes of carotid artery (large intima-media thickness and diastolic diameter and reduced artery distensibility) were significantly dominant in L and H groups than in N and S groups. These findings suggested that the findings of atherosclerotic plaque with low density core or calcification in carotid artery were closely related with cerebral ischemic changes. Therefore, we concluded that the carotid artery ultrasonography using acoustic densitometry method was useful for detect by an unstable state of atherosclerosis and cerebral ischemic changes in health screening.

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The aim of the present study was to determine whether the significance of hs-CRP among Japanese was available to predict the incidence of acute coronary syndrome.
Two thousand one hundred ten male subjects with age more than 40 years were followed up for 2.5 years in the cohorts in Tokyo. Seven cases developed acute coronary event through this period. They were hyperlipidemic and hs-CRP were higher than 1.0 mg/L (85percentile value). Incident rate was 5.87/1000 person year. None of the subjects with hs-CRP lower than 1.0 mg/L developed the events.
The results indicate that the determination of hs-CRP was valuable to predict the incidence of coronary heart disease among Japanese.

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The purpose of this study is to find out the relation of ABI, PWV and maximal oxygen uptake. Significant positive correlation was seen at the maximal oxygen uptake and ABI-R, ABI-L, BMI and baPWV-R, baPWV-L, and the age and each PWV value. These indexes might be the risk factor of the arteriosclerosis because relation to the arteriosclerosis parameter was admitted by each of the age, the maximal oxygen uptake and BMI. Therefore, it is suggested that to implement the moderate exercise regularly with both the quality and the quantity, and to maintain a physical strength level and to try fattenation prevention would contribute to the prevention of the arteriosclerosis.

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Obesity is the origin of life style disease. At our center, we classified the obesity person into 3 types (true, apparent, latent), and investigated the correlation between obesity and the factor of life style disease (hyperlipidemia, fatty liver, glucose intolerance and hypertension).
The relationship between types of obesity and life style disease resulted different between male and female.
We conclude that in showing the result of each person's biochemical data who has a factor of life style disease, we have to consider the difference of sex and types of obesity.

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The present study was conducted to examine the noninvasive Brachial-ankle pulse wave velocity (baPWV) /Ankle Brachial Index (ABI) measurements of the early stage of type II diabetes patients in our hospital. Compared with the normal control group, baPWV of the diabetic group was significantly increased (1594±31 vs1308±13 cm/sec, p<0.001). Although there were no diabetic factors which are significantly correlated with baPWV/ABI in a diabetic group, baPWV of the patients with microalbuminuria group was significantly increased (1758±55 vs1580±35 cm/sec, p<0.01). These data suggest that the arteriosclerosis of great vessels have already advanced also in the early stage of diabetes, and baPWV not only knows the grade of the arteriosclerosis of large vessels, but may be a useful predictor of development of diabetic nephropathy by arteriosclerosis of small vessels.

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We have studied the habit of exercise of 84 subjects with Diabetes mellitus undergoing human dry dock. The blood sugar level of 75gOGTT were improved in 41 subjects (48.8%)compared with the last year.6 subjects were acquired the new habit of exercise (5: walking,1: swimming). Remaining subjects were not acquired any habit of exercise, but they have the lifestyle with active walking and active daily life. It was proved that progress of diabetes mellitus was prevented by the “lifestyle walking”.

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To evaluate fatty liver with no obvious etiology, we examined male subjects who underwent our human dry dock. The somatic fatty rate (23.5 ± 3.2% vs.20.7± 3.7%, p<0.0001), the serum level of GOT (27.2±10.0U/L vs.22.6±6.9U/L, p< 0.001), GPT(35.8±21.6U/L vs.22.3±11.6U/L, p<0.0001), TG(164.7±124.8mg/dl vs.102.7±45.4mg/dl, p<0.0001), and HOMA-R (2.0±0.9 vs.1.3±0.6, p< 0.0001) of the subjects with fatty liver of which cause was unknown were significantly higher, and that of HDL-C (54.0 ± 11.9mg/dl vs.59.3± 13.4mg/dl, p< 0.01) was significantly lower than those of the normal subjects. In those subjects with fatty liver, the somatic fatty rate (r =0.2396, p =0.0115), the serum level of GOT (r=0.2313, p=0.0145), GPT (r=0.2809, p =0.0038), and TG (r=0.3335, p =0.0008)were positively correlated, and that of HDL-C (r=-0.2700, p=0.0048) was negatively correlated with that of HOMA-R. This result indicates that insulin-resistance caused by visceral-fat adiposity is related to the onset of fatty liver in those subjects whose BMI is less than 25 m²/kg. In conclusion, it is necessary to lead those subjects with fatty liver in the same way as visceral fat obesity.

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To assess the impact of fatty liver to lifestyle-related disease,197 fatty liver subjects were compared with 360 normal liver subjects in non-obese non-alcoholic patients. In fatty liver subjects, ALT, γ-GTP, total cholesterol, LDL-cholesterol, triglycerids, fasting plasma glucose level, HbA1c and uric acid level were statistically significant higher, lower in HDL-cholesterol, than in normal liver. The odds ratios of hyperlipidemia, impaired glucose tolerance in fatty liver were significant higher than in normal liver. Logistic regression analysis on background factors for fatty liver showed that only BMI had significant and the odds ratio was 1.76.

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Objectives: To elucidate the relation among the sexual functions of men in a health screening. Of the 858 men who underwent general health screening tests at the Center for Multiphasic Health Testing and Services between April and July in 2000,596 subjects completed the questionnaires. The questionnaire for sexual function with 11 questions was developed based on the Sapporo Medical University sexual function questionnaire. Factor analysis performed with SAS version 8.02. Factor analysis revealed that 11 questions could be clearly separated into 5 components with total variances of 80.3%, respectively. The five components cover erectile function, sexual drive, overall sex life, treatment for erectile dysfunction, and morning erection. An initial set of questions was refined and reduced through this study. We selected a brief inventory to measure male sexual function in a health screening. Further research is required to make a brief inventory to measure male sexual function in a health screening and to evaluate the validity of the questionnaires.

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To assess the duration for following up to decide the conclusive diagnosis of cervical carcinoma in women whose cytology is positive,195,228 women who underwent cervical cytological diagnosis at human dry dock, gynecological clinic, and population screening were examined, and followed up them completely for more than 10 years. Two hundred and twenty five cases were proved cervical carcinoma histologically by punch biopsy among 254cases whose cytology was positive.5 cases were false negative, and 7 cases were false positive. Predictive value was 96.98%, sensitivity was 97.82%, and specificity was 99.99%, respectively. Detection rate of cancer was 0.03% in human dry dock and populaltion screening, and 0.31% in gynecological clinic. Also, survival rate was better in human dry dock than in gynecological clinic. On the other hand,20% of cytological examination was missed at the first punch biopsy, and cancer was proven at second or third biopsy in 5 cases. Therefore, the duration for following up to reach conclusive diagnosis for whose cytology is positive will be 100days.

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The telephone-based health educations after routine health examinations were conducted for 437 [19.4%] of 2,251 examinees during the period from September 2,001 to march 2,002 in the human dry dock system of Mito Red Cross Hospital.
In this study, the contents of the telephone-based education cases were reviewed, and the significance of such health education system connected with health examinations was assessed. As the agenda of the education, the results of cytology from gastro-endoscopy was the most frequent. The internal medicine was the most frequently introduced division through the telephone counseling among all the divisions of the hospital.
It was considered that the aftercare for examinees through telephone counseling enables the clients to recognize their own health status and health problem more correctly and more clearly. Therefore, it would contribute to improving the effectiveness of health examinations to provide health promotion and primary prevention of diseases.

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To elucidate the relationship between the medical data(obese(BMI), blood pressure(BP), lipids, and plasma glucose) and life-style(drinking, smoking, taking or not taking snack and supper time), we assesed the degree of relationship according to the numerical scores based on the our own-made scale system in 6 occupations(banker, policeman, nurse, public official, manufacture man and businessman). Concerning the labo data and life-style, both businessman and policeman consisted with many obese patients, they got significantly high points among, six groups and there were significant correlationship between labo data and life-style, respectively. These data reveal that we must recognize the specific tendencies in the relationship between labo data and life-style in each occupations. Then we-medical staff as the members of health assesment and promotion should utilize those unique data to urge the patients to change and improve their behaviors.

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