Magnesium is an essential element to the human body, and Mg
2+ ion can work to enhance cell adhesion, proliferation, differentiation, and mineralization. From the viewpoint of inorganic glass formation, MgO can be classified as an intermediate, that improves the glass-forming and ion-releasing abilities. The present work reports fundamental data for designing MgO-containing bioactive phosphate glasses with manipulated ion-releasability. MgO-CaO-P
2O
5-TiO
2 invert glasses were prepared, in which TiO
2 was substituted by MgO, and their structure and dissolution behavior were examined. Magnesium in the glasses was preferentially bonded to orthophosphate groups. The glass-forming ability and chemical durability of the glasses decreased with increasing MgO content, since P-O-Mg bonds are weaker than P-O-Ti bonds. In contrast, the ion-releasing ability of the glasses improved with increasing MgO content, and the released amount of Mg
2+ ion was expected to be within the range suitable to stimulate cell adhesion and proliferation.
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