A 53-year-old female complained the slight pain and swelling of the marginal gingiva in the mandibular right first molar. Her mandibular right first molar was diagnosis as hopeless with clinical and radiographic examination and was extracted. The several treatment options for her missing tooth including an implant-supported crown, a removable partial denture, a tooth supported fixed bridge were proposed. The advantages and disadvantages of each treatment were comprehensively explained to her. She strongly hoped no to sacrifice her natural teeth, and rejected all of the above treatments. We then proposed to her a novel devised minimally invasive prosthodontic treatment modality that was a tooth-supported removable bridge without tooth preparation named “non-preparation removable bridge (NPRB)”. She thus decided to choose the NPRB treatment. The NPRBs were made of the following two CAD/CAM polymeric materials by using CAD/CAM technology; polymethyl methacrylate (PMMA) and polyetheretherketone (PEEK), the latter one has been widespread in the dental field, such as denture framework, dental crown, bridge, and dental implant, because of its favorable physical, mechanical and chemical properties. After wearing the NPRBs, usability tests were conducted. As a result of subjective and objective results of usability testing of the NPRBs, the PEEK-NPRB received higer evaluation than the PMMA-NPRB. Finally, the patient decided to use the PEEK-NPRB. One-year successful clinical follow-up was done. The patient was very satisfied with the good wear feeling and the function of the NPRB. The NPRB treatment is less time consuming than other treatment approaches, and the suitable treatment option for the patient who rejected more invasive treatment options.