The human dental caries pathogen
Streptococcus mutans harbors one glucan-binding wall-anchored protein gene, g
bpC, and another human pathogen,
Streptococcus sobrinus, has 4
gbpC homologues. As no 4
gbpC homologues have so far been detected in other mutans streptococci, however, we cannot say whether those in
S. sobrinus are paralogous or orthologous. Therefore, the purpose of this study was to identify and sequence the
gbpC/dbl genes in
Streptococcus downei and
Streptococcus criceti. The findings revealed that the former harbored 5
gbpC/dbl homologues and the latter 4. In addition, another
dbl homologue, the
dblC gene, was found in some strains of
S. sobrinus. We performed a phylogenetic analysis with the
gbpC/dbl genes in these mutans streptococci. These results indicate that the
gbpC and
dbl genes have an orthologous relationship.
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