Oxidative stress influences the pathologic development of many diseases. Vascular endothelial cells are particularly vulnerable targets for reactive oxygen. In this report, we examine the physiological changes, cell viability, induction of HSP 70 and the clotting and fibrinolytic factors of vascular endothelial cells under oxidative stress from hydrogen peroxide. Under such stress from 0.0003% to 0.003% hydrogen peroxide, the expression of HSP 70 increased 2.5-fold compared with that of the control. The production of PAI-1 of vascular endothelial cells tended to increase up to 0.003% hydrogen peroxide. The cell viability and tPA production of vascular endothelial cells decreased only once (00.001%), but then held steady (0.0010.003%). When oxidative stress exceeded 0.003% hydrogen peroxide, the induction of HSP 70, cell viability, and the tPA and PAI-1 production of vascular endothelial cells decreased.
Thus, under oxidative stress, vascular endothelial cells virtually always expressed HSP 70 in response, and would be cytoprotected by induced HSP 70, and the blood clotting and fibrinolytic systems depended on coagulation. Under the excessive oxidative stress (over 0.003% hydrogen peroxide), all of them (cell viability of HUVEC, production of tPA and PAI-1 and expression of HSP 70) decreased.

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The performance of a capacitive and a radiative annular phased array applicator for regional hyperthermia is compared in a model study, for an agar-bone phantom and a structured patient anatomy with a prostate tumour. The capacitive applicator is a model of the Thermotron RF8 device, operating at 8 MHz. Its performance is improved by the use of very cold overlay boli with a suitable salinity. The radiative applicator is a three ring, cavity slot annular array applicator, operating at 150 MHz. The Specific Absorption Rate (SAR) distribution in the cavity slot applicator is optimized by phaseamplitude control. Comparison of both SAR and thermal distributions shows that the radiative applicator can generate good tumour heating in the pelvic region and avoid the overheating of superficial fat layers and muscle tissue seen in the capacitive applicator.

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The basic treatment for gastric carcinoma is surgical resection. Recently however, in order to shrink the tumor, combined modality therapy has been performed for far-advanced gastric cancer and recurrent tumor following surgery. We report two cases of gastric carcinoma treated with remarkably effective hyperthermo-chemo-radiotherapy. The patients had advanced gastric cancer with invasion to the esophagus and stomal recurrent tumor after total gastrectomy. The tumors completely disappeared after the treatment, and the two patients have survived more than a decade since the beginning of treatment. It is considered that hyperthermo-chemo-radiotherapy is useful for some gastric cancers as an option in combined modality therapy.

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Fifty four-year-old patient with unresectable hypopharyngeal cancer of T4N2cM0 was treated with accelerated hyperfractionated radiotherapy (1.5Gy twice a day) and hyperthermia. Good tumor response was achieved by combined four sessions of hyperthermia with radiotherapy of 75Gy. Laryngopharyngectomy, cervical esophagectomy, and bilateral neck dissection were performed for regrowth of the primary site 2.5 months after thermoradiotherapy. There were no viable cells in all metastatic nodes although scattered cancer nests were seen in the primary site.
He has a local disease-free eleven months after resection.

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