Annual Meeting of the Japanese Society of Toxicology

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The 35th Annual Meeting of the Japanese Society of Toxicology

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Mechanisms

Mechanism-based biomarker gene sets for glutathione-depletion

Weihua Gao, Noriyuki Nakatsu, Yosuke Minowa, Hiroshi Yamada, Toshikazu ...

Session ID: P-039
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.151.0

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Knockdown of superoxide dismutase 2 and expression of CYP3A4 to investigate drug-induced cytotoxicity test

Yukitaka YOSHIKAWA, Hiroko HOSOMI, Miki KATOH, Miki NAKAJIMA, Tsuyoshi ...

Session ID: P-040
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.152.0

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Effects of organochlorine (DDT) on the central nervous system of immature rats

Yasufumi Shutoh, Atsuko Haishima, Ryoichi Ohtsuka, Satoru Yamaguchi, Y ...

Session ID: P-041
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.153.0

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TGF-beta1/smad2/3-mediated Pulmonary Fibrosis Following Intratracheal Instillation of Didecyldimethylammonium Chlorides (DDAC) in Mice.

Aya Ohnuma, Haruka Tajima, Toshinori Yoshida, Satoru Yamaguchi, Ryoich ...

Session ID: P-042
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.154.0

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Pulmonary injuries by combined intratracheal administration of oxidative stress inducers chromium (VI) and arsenate (V) in male C57BL/6 mice

Haruka Tajima, Aya Ohnuma, Toshinori Yoshida, Tomoki Fukuyama, Koichi ...

Session ID: P-043
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.155.0

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Influence of estrogen on gender-difference in drug-induced QT prolongation

Mahoko Asayama, Masaji Tamagawa, Haruaki Nakaya, Tetsushi Furukawa, Ju ...

Session ID: P-044
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.156.0

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In vitro and In vivo Cardiac Electrophysiological Effects of Proton Pump Inhibitors

Naoki Watanabe, Yasuo Nakamura, Wen-ge Yu, Tatsumi Inui, Kazuaki Sasak ...

Session ID: P-045
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.157.0

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Histopathological effect of ketoconazole on rat placenta

Satoshi Furukawa, Seigo Hayashi, Koji Usuda, Masayoshi Abe, Izumi Ogaw ...

Session ID: P-046
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.158.0

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Involvement of protein phosphatase type 1 (PP1) in arsenic toxicity

Tsutomu Takahashi, Naoyuki Miyanaga, Takako Niwa, Akira Naganuma

Session ID: P-047
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.159.0

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Investigation of toxicological mechanism for rat cornea opacity induced by alkylalkanolamine.

Tamio Fukushima, Junko Abe, Yoshimasa Hamada, Ikuo Horii

Session ID: P-048
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.160.0

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Toxic effects of carbon tetrachloride in pregnant rabbits

Yasumoto MIZOGUCHI, Ryo KAMATA, Ema SANO, Hiroyasu MIZUGUCHI, Ttsutomu ...

Session ID: P-049
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.161.0

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Tyrosine kinase inhibitors cause cardiotoxicity?

Shunji Nomura, Yoshimasa Hamada, Ikuo Horii

Session ID: P-050
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.162.0

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Surveillance study

A continued survey on serious adverse events in phase I clinical studies (3rd report)

Yasumoto Kikuchi, Ichiro Fukazawa, Hajime Iijima, Tsuyoshi Momma, Hiro ...

Session ID: P-051
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.163.0

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An evaluation of the urinary biogenic amine levels for the prediction of postoperative nausea and vomiting

Masahiro Nemoto, Junko Kowada, Toru Endo, Masahiko Hirafuji, Hideya Sa ...

Session ID: P-052
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.164.0

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Urinary Excretion of 3-Phenoxybonzoic Acid in General Population in Japan

JUN UEYAMA, AKIKO KIMATA, MICHIHIRO KAMIJIMA, KENJI TAKAGI, SHINYA WAK ...

Session ID: P-053
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.165.0

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JPMA survey on duration of chronic non-rodent toxicity studies for pharmaceuticals in ICH-M3(R2) guideline

Kazuto Watanabe, Eiji Hosoki, Hajime Matsui, Syuji Ogawa, Mitsuru Koba ...

Session ID: P-054
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.166.0

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JPMA survey on predictivity of preliminary embryo-fetal developmental toxicity studies for timing of embryo-fetal developmental toxicity studies in ICH-M3(R2) guideline

Noriko Okahashi, Takashi Ikeda, Shuichi Kai, Shinichi Komatsu, Hajime ...

Session ID: P-055
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.167.0

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Questionnaire data for effective design of reproductive and developmental toxicity study

MASAYUKI UBE, SATOSHI KUDOU, TOSHIHIKO KUMAZAWA, SHINICHI KOMATSU, ATS ...

Session ID: P-056
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.168.0

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Comparison of dose and pharmacokinetic parameters between non-toxic dose in animals and clinical dose in human using recent marketed drugs (1999-2006)

Hidetoshi SHINDOH, Hiroko IGARASHI, Motohiro KATO, Masaki ISHIGAI, Yos ...

Session ID: P-057
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.169.0

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Comparison of pharmacokinetic parameters between species using clinical and preclinical data of recent marketed drugs(1999-2006)

Hiroko IGARASHI, Hidetoshi SHINDOH, Motohiro KATO, Masaki ISHIGAI, Yos ...

Session ID: P-058
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.170.0

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Staff Training and Development in Contract Research

Lesley Earl

Session ID: P-059
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.171.0

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Experimental animal, Animal models

Similarity and difference of the peripheral neuropathies in rats induced by paclitaxel or oxaliplatin.

Takahisa Yano, Takehiro Kawashiri, Mariko Sakurai, Shingo Hirakawa, Me ...

Session ID: P-060
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.172.0

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Strain differences in metabolic response to a high-fat diet in rats

Hideaki Yokoyama, Taku Masuyama, Yusuke Suzuki, Naoko Morimoto, Takuya ...

Session ID: P-061
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.173.0

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Sensitivity of liver injury in mitochondrial toxicity model (Sod2+/- mice): Studies using troglitazone and acetaminophen

Kazunori Fujimoto, Kazuyoshi Kumagai, Kazumi Ito, Shingo Arakawa, Yosu ...

Session ID: P-062
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.174.0

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Study for evaluation of acetic acid colitis in dogs

Katsuhiko Hori, Ayahito Kimura, Noriko Minobe, Miki Shirahata, Kaori M ...

Session ID: P-063
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.175.0

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An animal model of pre-symptomatic serum diagnosis of pancreatic ductal carcinomas

Katsumi Fukamachi, Yoshiaki Hagiwara, Hajime Tanaka, Kazuyoshi Yanagih ...

Session ID: P-064
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.176.0

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Carcinogenic comparative study on rasH2 mice produced by two breeding facilities

Kazuhiko Machida, Koji Urano, Masumi Yoshimura, Hideki Tsutsumi, Tatsu ...

Session ID: P-065
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.177.0

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Serum biochemical and histological properties in each genotype of Zucker rats

Young-Man Cho, Toshio Imai, Shigeaki Takami, Akiyoshi Nishikawa

Session ID: P-066
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.178.0

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The evaluation and construction of mouse exposure to estrogen in fetal life by placenta-specific gene transduction using lentiviral vector

ICHIRO YOSHIDA, YUICHIRO SUMI, YUKIE AZUMA, YUKA OKADA, MASARU OKABE, ...

Session ID: P-067
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.179.0

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Exogenous diurnal fluctuation of plasma biochemistry parameters in cynomolgus monkeys

Takeshi Sato, Takafumi Shirakawa, Hajime Tabata, Kouji Watanabe, Takej ...

Session ID: P-068
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.180.0

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Auditory Brainstem Response in Cynomolgus Monkeys

Yuichi Tsuda, Kyohei Sugimoto, Takuto Yokota, Takahiro Tanaka, Kohsuke ...

Session ID: P-069
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.181.0

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Neuro-behavioral study and percellome analysis in estrogen receptor alpha knock-down mice.

Kentaro Tanemura, Katsuhide Igarashi, Ken-ichi Aisaki, Satoshi Kitajim ...

Session ID: P-070
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.182.0

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Changes in placental histology during pregnancy of rabbits

Kazuko Tsurumoto, Maki Noguchi, Tomoko Gotoh, Minatsu Haruki, Mariko O ...

Session ID: P-071
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.183.0

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Changes in blood parameters in Kbl:Japanese white rabbits during pregnancy

RYO KAMATA, TAKAKO ENDOH, KAZUYA HUKUDA, HIROYASU MIZUGUCHI, YASUMOTO ...

Session ID: P-072
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.184.0

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The effect of dietary ingredients on values of blood coagulation parameters in rats

Yasuyuki Ohnishi, Misako Okano, Hiroyuki Ishii, Atsuko Ohnobu, Hideaki ...

Session ID: P-073
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.185.0

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Changes in blood parameters during the lactation period in rats

Yoshinaka Urasoko, Xi Jun He, Masao Takano, Junko Ogawa, Masanobu Uema ...

Session ID: P-074
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.186.0

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Relationship between estrus cycles and plasma hormone in rats

Hajime Wada, Takafumi Ohta, Akane Takahashi, Kinuko Zaizen, Yukihiro N ...

Session ID: P-075
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.187.0

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Age-related changes of blood hormone levels in rats

Yukihiro NAKASHIMA, Junko HANGAI, Kinuko ZAIZEN, Yasuhiko NAKAMURA, Km ...

Session ID: P-076
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.188.0

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Usability Assessment and Improvement of a Hematology Analyzer (XT-2000iV) for Hematological Examination in Miniature pigs

Takahiko NAGASE, Kenji HORINOUTI, Sinsuke SUZUKI, Yasunori ODA, Kimiyo ...

Session ID: P-077
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.189.0

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Age-related changes of bone metabolism markers in rats

Daisuke SASAKI, Michie SUZUKI, Hajime TABATA, Akira MORIGUCHI, Takao T ...

Session ID: P-078
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.190.0

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Carcinogenesis

Investigation of the strain differences in medium-term rat liver bioassay

Hikaru ITO, Takahiro ONO, Miyuki OGAWA, Mayumi KAWABE, Akihiro HAGIWAR ...

Session ID: P-079
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.191.0

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In vivo liver initiation activity of diheptyl phthalate in rats

Meilan JIN, Yasuaki DEWA, Jihei NISHIMURA, Masaomi KAWAI, Yukie SAEKUS ...

Session ID: P-080
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.192.0

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Site-specific molecular pathological analysis in the formation phase of liver tumor in rats treated with fenofibrate

Jihei Nishimura, Yasuaki Dewa, Meilan Jin, Yukie Saegusa, Masaomi Kawa ...

Session ID: P-081
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.193.0

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Piperonyl butoxide induced oxidative DNA damage and in vivo mutagenicity in the livers of gpt delta rats

Masako Tasaki, Tomoki Inoue, Toshiya Okamura, Yuji Ishii, Hisayoshi Ta ...

Session ID: P-082
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.194.0

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DNA methylation profiling during the promotion stages of mouse hepatocarcinogenesis

MASAOMI Kawai, MAKOTO Shibutani, MAMI U, MIWA Takahashi, YASUAKI Dewa, ...

Session ID: P-083
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.195.0

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Inhibitory effects of prepubertal administration of decabromodiphenyl ether on susceptibility to thyroid and renal carcinogenesis in rats exposed to DHPN and DMBA during adolescence

Shigeaki Takami, Toshio Imai, Young-Man Cho, Masao Hirose, Akiyoshi Ni ...

Session ID: P-084
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.196.0

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Drug metabolism

Nrf2 mediated induction of Cyp2b10 gene expression

Takemi Yoshida, Haruyo Okubo, Takashi Ashino, Masayuki Yamamoto, Satos ...

Session ID: P-085
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.197.0

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Expression pattern of drug metabolizing enzymes and its individual differences in human livers.

Shuko Hata, Yasuhiro Miki, Fumiyoshi Fujishima, Ryuichiro Sato, Michia ...

Session ID: P-086
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.198.0

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Association of the G134A and G184C polymorphisms in the CYP1A1 gene

Jung-Duck Park, Jae Chul Choi, Byung-Sun Choi, Ryu Doug-Young

Session ID: P-087
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.199.0

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Effects of food additives on 3-methylchorenthrene-mediated induction of CYP1A subfamily enzymes in HepG2 cells.

Masashi SEKIMOTO, Kiyomitsu NEMOTO, Akiyoshi NISHIKAWA, Masakuni DEGAW ...

Session ID: P-088
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.200.0

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