Annual Meeting of the Japanese Society of Toxicology

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The 35th Annual Meeting of the Japanese Society of Toxicology

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Challenges for infant drug development

Methods of Nonclinical Toxicology Studies in Juvenile Animals

Takashi Shibano

Session ID: W2-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.51.0

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Workshop 3

Risk Assessment of genotoxic contaminants

Classification and permissible amount of genotoxic impurity in pharmaceuticals

Masamitsu Honma

Session ID: W3-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.52.0

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Genotoxic Impurities in Pharmaceuticals: Regulatory Concerns and Industry Responses

Lutz Mueller

Session ID: W3-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.53.0

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Threshold of genotoxic carcinogens

Shoji Fukushima

Session ID: W3-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.54.0

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Risk Assessment for Genotoxic Impurities in Pharmaceuticals

TADASHI INOUE

Session ID: W3-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.55.0

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Workshop 4

Drug risk management from Pre-market to Post-market-II: An approach to safety science

The possibility of safety science based on linkage between pre- and post-marketing phases -- investigation of the mechanisms of serious adverse drug reactions – the promise of a science-based approach using preclinical safety information --

Mitsuyoshi Hara

Session ID: W4-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.56.0

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The Serious Adverse Event Consortium, Ltd. [SAEC] - Formation and Current Status of an International Effort to Understand the Genetic Basis of Drug Related Serious Adverse Events.

Arthur L. Holden

Session ID: W4-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.57.0

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Post-Marketing Safety Management in Japan (Toward the Development of Safety Measures throughout product's Lifecycle)

Akira Kawahara

Session ID: W4-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.58.0

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Workshop 5

Proposed Revision of ICH-M3 guideline and its practical challenges

Introduction

YASUO OHNO

Session ID: W5-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.59.0

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Outline of ICH-M3(R2) Guideline Step2 - a topic focused on single and repeated dose toxicity studies

Kenichi Nakazawa

Session ID: W5-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.60.0

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ICH revised guidance in genotoxicity testings

Masamitsu Honma

Session ID: W5-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.61.0

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Timing of Reproductive and Developmental Toxicity Studies

Noriko Okahashi

Session ID: W5-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.62.0

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Nonclinical Safety Information Required for Exploratory Clinical Studies

Keiji Yamamoto

Session ID: W5-5
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.63.0

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Workshop 6

Toxicology Question Box 2008

First session: Laboratory techniques in juvenile animal studies

Kazuhiro Shimomura, Ichiro Naeshiro, Toshihito Kadota

Session ID: W6-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.64.0

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2nd Session: How to proceed toxicity studies for developing biotechnology-derived pharmaceuticals

Ichiro Naeshiro, Kazuhiro Shimomura, Toshihito Kadota

Session ID: W6-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.65.0

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Oral Session

1. Endocrine system/ Environmental toxicology

Prenatal and neonatal exposure to bisphenol-A affects histone deacetylase (HDAC) expression

Daigo Ikegami, Minoru Narita, Yuri Tsurukawa, Keisuke Mizuo, Satoshi I ...

Session ID: O-01
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.66.0

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In-utero and lactational exposure of PCB126 modulate BBN-induced rat mammary carcinogenesis

Yousuke Kamei, Yasuko Kobayashi, Tomoko Muto, Kiyofumi Yokoo, Hitoshi ...

Session ID: O-02
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.67.0

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Expression of Steroid and Xenobiotic Receptor and its function in human bone tissues

Yasuhiro Miki, Shuji Nagasaki, Shuko Hata, Jun-ichi Akahira, Takashi S ...

Session ID: O-03
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.68.0

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Effects of Bispenol A on differentiation, proliferation and senescence in normal human mammary epithelial cells

Hideko Sone, hiroko zaha, Satoshi Imanishi, Tomokazu Fukuda, Yumi Mats ...

Session ID: O-04
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.69.0

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Investigation of developmental anomaly caused by phenolic environmental chemicals

KAZUNOBU BABA, KAZUSHI OKADA, SUSUMU IMAOKA

Session ID: O-05
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.70.0

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Monitoring of PPCPs in Aquatic Environment and Chronic Toxicity of Diclofenac to Fish

Masanori Seki, Junji Azuma, Ryuta Adachi, Reiji Kubota, Kingo Nakazono

Session ID: O-06
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.71.0

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2. Carcinogenesis

Influential effect of Connexin 32 expression on rat hepatocarcinogenesis

Makoto Asamoto, Tomoyuki Shirai

Session ID: O-07
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.72.0

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Development of oral carcinogenesis model using Hras128 transgenic rat

MASUMI SUZUI, KUNIKO NAOI

Session ID: O-08
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.73.0

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Role of biological function of the aryl hydrocarbon receptor

Yoko Hirabayashi, Guang-Xun Li, Byung-Il Yoon, Yoshiaki Fujii-Kuriyama ...

Session ID: O-09
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.74.0

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In-utero and lactational exposure of PCB126 modulate BHP-induced rat lung carcinogenesis

Yasuko Kobayashi, Tomoko Muto, Kiyofumi Yokoo, Hitoshi Endou, Yoshikat ...

Session ID: O-10
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.75.0

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Molecular expression analysis of drug metabolizing enzymes and cell cycle-related genes fluctuated during beta-naphthoflavone-induced tumor promotion in rats liver

YASUAKI DEWA, JIHEI NISHIMURA, MEILAN JIN, MASAOMI KAWAI, YUKIE SAEGUS ...

Session ID: O-11
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.76.0

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Sidestream smoke induces phosphorylation of histone H2AX

Tatsushi Toyooka, Yuko Ibuki

Session ID: O-12
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.77.0

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3. Mechanisms I (Liver)

Involvement of N-hydroxy metabolite and GSH in flutamide-induced hepatotoxicity

Masaaki Miyata, Masato Ohbuchi, Daichi Nagai, Yasushi Yamazoe

Session ID: O-13
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.78.0

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Neutralization of IL-10 exacerbates cycloheximide-induced hepatocellular apoptosis and necrosis

Kazuyoshi Kumagai, Kazumi Ito, Yosuke Ando, Ryota Kawai, Takashi Yamot ...

Session ID: O-14
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.79.0

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Effects of chemicals inducing hepatic hypertrophy on serum total cholesterol level: for safety evaluation of chemicals.

Kiyomitsu Nemoto, Akio Kobayashi, Midori Yoshida, Akiyoshi Nishikawa, ...

Session ID: O-15
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.80.0

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Involvement of iPLA2 in troglitazone-indued mitochondrial toxicity

Takuya Okuda, Yoshihisa Shitara, Toshiharu Horie

Session ID: O-16
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.81.0

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Effects caused by carbon tetrachloride on the liver of pregnant and lactating rats

satomi shimizu, kazuhiko umeshita, takashi kamata, takahiro kitazawa, ...

Session ID: O-17
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.82.0

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Toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole (HDBB) in rats - blood concentration and hepatic drug metabolizing enzyme activity -

Mutsuko Hirata-Koizumi, Kiyomi Matsuno, Mitsuhiko Kawabata, Kanako Yaj ...

Session ID: O-18
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.83.0

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Identification of biomarker genes correlated with anemia in the rat liver treated with myelosuppressive compounds

Chiaki Kondo, Takeki Uehara, Toshiyuki Maruyama

Session ID: O-19
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.84.0

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4. Mechanisms I I (Kidney, Immune system, Hematopoietic system, Nervous system )

Role of Epithelial-mesenchymal transition in renal interstitial fibrosis induced by cisplatin

Yoshiko Kawai, Tomohiko Satoh, Yukihiro Ohno, Munekazu Gemba

Session ID: O-20
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.85.0

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Interaction of human organic anion transporters (hOATs) with contrast media, Iodipamide.

NAOHIKO ANZAI, SUPARAT KHAMDANG, SUNENA SRIVASTAVA, YOSHIKATSU KANAI, ...

Session ID: O-21
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.86.0

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Evaluation of nephrotoxicity by quantitative analysis of urinary kidney injury molecule 1

masafumi nagata, kiyotaka mochiduki, junji onoda, toshinaga tsuji, mak ...

Session ID: O-22
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.87.0

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Renal toxicity in new born rats exposed to uranium acetate

Shino Takeda, Miyuki Inoue, Shyunji Ueno, Mayumi Nishimura, Yoshiya Sh ...

Session ID: O-23
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.88.0

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Heat shock suppresses human NK cell cytotoxicity via regulation of perforin

Hideki Harada, Toru Murakami, Seow Shi Tea, Akira Takeuchi, Tomoaki Ko ...

Session ID: O-24
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.89.0

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Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in aged mouse after 5-fluorouracil treatment

Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada, Yukio Kodama, Jun Kann ...

Session ID: O-25
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.90.0

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Early hemolytic anemia in Rats following a single administration of acetylhpenylhydrazine

Sayuri KOJIMA, Junya SASAKI, Mariko TOMITA, Yasufumi SYUTOH, Aya OHNUM ...

Session ID: O-26
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.91.0

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involvement of IL-1 in LPS-induced learning and memory deficits

Sachiko Tanaka, Kingo Kanda, Tomoya Nakamachi, Seiji Shioda, Satoshi N ...

Session ID: O-27
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.92.0

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5. Cardiovascular toxicology

The usefulness of Langendorff guinea pig heart model in drug-induced QT prolongation risk assessment

Ryuichi Komatsu, Mitsuyasu Tabo, Yuichiro Yamada, Masaki Honda, Kazuya ...

Session ID: O-28
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.93.0

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Evaluation of drug-induced QT prolongation in halothane-anesthetized and conscious cynomolgus monkeys treated with sotalol

Tomomichi Ishizaka, Yu Yoshimatsu, Minori Ozawa, Tomofumi Kimotsuki, S ...

Session ID: O-29
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.94.0

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Clinical significance of troponins as myocardial damage biomarkers in cynomolgus monkeys.

Hirofumi Minomo, Ayako Setoguchi, Hiroshi Uchino, Takeshi Fukuda, Yusu ...

Session ID: O-30
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.95.0

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Proarrythmic effect of Moxifloxacin in Chronic AV Block Monkeys administered by intravenous infusion

Kengo Sakamoto, Kazuya Tabata, Yoshio Wakasa, Hiroko Miyazaki, Yuji Mo ...

Session ID: O-31
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.96.0

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Evaluation of the holter ECG in cynomolgus monkeys

Sou WADA, Masahiko NAKASE, Atushi KUMANO, Norio HIKE, Yoshimasa KURATA ...

Session ID: O-32
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.97.0

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Electroretinographic assessment of rod and cone function in cynomolgus monkeys :Effects of intramuscular administration of digoxin

Junzo kinoshita, Mitsuhiro Ohba, Takanori Maejima, Yu Yoshimatsu, Tomo ...

Session ID: O-33
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.98.0

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6. Nanomaterial toxicology

Acute toxicity of fullerene C60 to Daphnia magna

Ryuta Adachi, Saori Fujishima, Yuki Gondo, Yoshiyuki Inoue, Masanori S ...

Session ID: O-34
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.99.0

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Induction of mesothelioma by an intrascrotal administration of multi-wall carbon nanotube in male Fischer 344 rats

Yoshimitsu Sakamoto, Nobutaka Fukumori, Shinichi Uehara, Akihiko Hiros ...

Session ID: O-35
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.100.0

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