Annual Meeting of the Japanese Society of Toxicology

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The 36th Annual Meeting of the Japanese Society of Toxicology

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Drugs and Chemicals, Safety Assessment, ect.

Establishment of Knockdown of Superoxide Dismutase 2 System to Evaluate Drug-induced Hepatotoxicity

Yukitaka YOSHIKAWA, Hiroko HOSOMI, Mayu MORITA, Koichi TSUNEYAMA, Tats ...

Session ID: P-139
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4139.0

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Assessment of respiratory fanctions by infusion administration in rats

manami chihara, yasue sakaguchi, akira kubodera, fumio masaki, yasuki ...

Session ID: P-140
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4140.0

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Effect of fasting and refeeding on clinical pathological parameters in rats

TAKASHI YAMAGUCHI, MIWA SAWADA, SYUJI OGAWA, TOSHIKO KINOMOTO, MASATAK ...

Session ID: P-141
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4141.0

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Differences in laboratory test values in cynomolgus monkeys depending on breeding facilities

Koji Otabe, Yoko Matsuzawa, Yoshio Wakasa, Yoshitaka Hirasawa, Masaaki ...

Session ID: P-142
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4142.0

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JPMA survey on the starting dose in the first in human clinical trial of anticancer pharmaceuticals

Shuichi KAI, Chihiro NISHIMURA, Jiro MANIWA, Takeshi SHIBAHARA, Yuko M ...

Session ID: P-143
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4143.0

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The Minipig: The Non-Rodent Species in the Safety Evaluation of Topical Drug Products

Harvey Warren, Danks Andy

Session ID: P-144
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4144.0

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Simultaneous Assessment of the Safety Pharmacology Core Battery in Large Animal Species

Christopher Chengelis, Kenneth Kearney, Philip Atterson

Session ID: P-145
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4145.0

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Method of automatic intravenous infusion in freely moving cynomolgus monkeys

Kanta KAWABATA, Norio ODAGIRI, Katsuhiko SAKAI, Mototsugu SAKAKIBARA, ...

Session ID: P-146
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4146.0

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The Assessment of Stress in Cynomolgus Monkeys

Harvey Warren, Thompson Naomi, Reid Claire, Jacob Lawrence

Session ID: P-147
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4147.0

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The analysis of hematological abnormality using an automated blood cell analyzer (XT-2000i) in aged rats and mice

Chie HIRATANI, Yasuyuki OHNISHI, Hideaki HIRATSUKA

Session ID: P-148
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4148.0

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In silico assessment of repeated dose toxicity -Construction of mechanistic category of industrial chemicals inducing methemoglobinemia and hemolysis-

Takashi Yamada, HuiQi Zhang, Yushiro Tanaka, Jun Yamada, Akihiko Maeka ...

Session ID: P-149
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4149.0

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The development of the 2-stage skin carcinogenicity study using rasH2 mice

Mayumi kawabe, Mayuko Suguro, Miyuki Ogawa, Fumio Furukawa, Kouji Uran ...

Session ID: P-150
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4150.0

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Combined toxicity of organophosphates: Effects of repeat oral administration of parathion and methamidophos mixture in rats

Yasufumi Shutoh, Tomoki Fukuyama, Hideaki Fujie, Sayuri Kojima, Mariko ...

Session ID: P-151
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4151.0

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Neurobehavioral assessments for drugs in cynomolgus monkeys

Yosuke Ochiai, Makoto Hiroyasu, Norio Gotou, Atsushi Kumano, Yoshihiro ...

Session ID: P-152
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4152.0

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Glucocorticoid receptor (GR) genetic polymorphism and stress sensitivity - Studies using the mouse-

Masafumi Tomita, Toshiko Okuyama, Yoko Watanabe, Kazuo Hidaka, Hironob ...

Session ID: P-153
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4153.0

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Combination method of triple- dose micronucleus test and comet assay

Shuichi Hamada, Hiroyuki Ishii, Yuri Kotani, Hironao Takasawa, Kazunor ...

Session ID: P-154
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4154.0

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Contribution of hyperglycemia to DNA damage via ROS reaction in KK-Ay mice

Kazuyuki HASHIMOTO, Wataru TAKASAKI, Takashi YAMOTO, Sunao MANABE, Ita ...

Session ID: P-155
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4155.0

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An Investigation on Integration of micronucleus test into general toxicity study - Effects of TK Blood Collection on the Study results -

Hiroyuki Ishii, Masayoshi Kawabata, Naoaki Yamada, Syuuichi Hamada

Session ID: P-156
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4156.0

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Safety Evaluation for Chiral Pharmaceuticals (2) – Investigation of NDA Documents and Assessment Reports in Japan –

Toshiya YAMAGUCHI, Takashi NAGAYAMA, Takashi KIMURA, Nobuhiko KOWATA, ...

Session ID: P-157
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4157.0

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Toxicity profile of maraviroc, a CCR5 antagonist, in preclinical assessment

Masanori Hizue, Toshiaki Hayashi, Shunji Nomura, Yoshimasa Hamada

Session ID: P-158
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4158.0

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Safety Evaluation for Chiral Pharmaceuticals (1) – Questionnaire Survey of Japan Pharmaceutical Manufacturers Association –

Takashi KIMURA, Takashi NAGAYAMA, Toshiya YAMAGUCHI, Nobuhiko KOWATA, ...

Session ID: P-159
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4159.0

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Toxicity profile of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in preclinical assessment

Masanori Hizue, Toshiaki Hayashi, Shunji Nomura, Yoshimasa Hamada

Session ID: P-160
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4160.0

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Experimental research on allergic manifestations in newborns from exposure to chemicals during fetal life. -Anaphylactoid reactions in rats sensitized to ovalbumin during fetal life-

Tsuyoshi Higuchi, Akemi Yamada, Kumiko Honda, Hideomi Uchida, Kunio Ka ...

Session ID: P-161
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4161.0

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Study of oral phototoxicity methods in SD rats - Comparison of 5 typical phototoxic substances -

Yoshiyuki TAZURA, Tomomi MORIMURA, Satoko AOKI, Hajime SUI, Kumiko KAW ...

Session ID: P-162
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4162.0

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Acute toxicity of 60 kHz magnetic field in the rat

Izumi Nishimura, Setsuo Imai, Tadashi Negishi

Session ID: P-163
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4163.0

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A study for the differences between Wistar Hannover and Sprague Dawley rats in toxicology parameters.

Nobuhiko Arisaka, Shinichi Muto, Yuji Okuhara, Shigeru Matsumi, Yasuta ...

Session ID: P-164
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4164.0

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Effects of gelatin capsules on glucose-related parameters in dogs

Hideaki Yokoyama, Taku Masuyama, Tomio Ishida, Yusuke Suzuki, Akio Kob ...

Session ID: P-165
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4165.0

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Changes in Blood Coagulation-related Parameters in Rabbits treated with Phenobarbital

Hajime Abe, Masahiro Mochizuki, Kei Wakabayashi, Hiroyasu Yoshinaga, E ...

Session ID: P-166
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4166.0

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Nicotine-induced depression-related behavioral alterations and roles of vanilloid and cannabinoid receptors

Tamaki Hayase

Session ID: P-167
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4167.0

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Comparisons of toxicity of dexamethasone between Crl:CD(SD) and Slc:Wistar Hannover/Rcc rats

Rei YAMANA, Shunsuke TSUTSUMI, Masaki WAKAMATSU, Yukari ORIHARA, Chihi ...

Session ID: P-168
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4168.0

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28-day Repeated Dose Toxicity Study of Black Soybean Extract in Crj:CD(SD)IGS Rats

Akihiro Hagiwara, Norio Imai, Takamasa Numano, Hironao Nakashima, Seik ...

Session ID: P-169
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4169.0

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Ninety-days subchronic toxicity study of Shikon color in F344 rats.

Yuta Suzuki, Aki Kijima, Masako Tasaki, Tomoki Inoue, Toshiya Okamura, ...

Session ID: P-170
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4170.0

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Relationship between elevated liver G6PD activity and plasma insulin level in stroke-prone spontaneously hypertensive rats given canola oil

Shigehiro TACHIBANA, Toru FUKUMITU, Mari OKIMOTO, Tomoko NAGATA, Yukik ...

Session ID: P-171
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4171.0

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Tissue distribution and toxicity of titanium dioxide particles in rats after repeated topical application

Yoshiaki Ikarashi, Yoko Takita, Tomoko Obama, Tadashi Uchino, Tetsuji ...

Session ID: P-172
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4172.0

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Experimental study on the intracellular localization in mice treated with nano materials

Takayoshi Imazawa, Akihiro Arimori, Masaaki Isobe, Hiromi Nabeshi, Yok ...

Session ID: P-173
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4173.0

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Investigation on promoting potential of titanium dioxide (coated and non-coated) in a two-stage skin carcinogenesis model using mice

Yuko Doi, Mayuko Suguro, Tomomi Hara, Hikaru Ito, Fumio Furukawa, Osam ...

Session ID: P-174
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4174.0

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Detection of endocrine activity in 4,4'-Cyclohexylidenebisphenol and 2-Hydroxy-4-methoxybenzophenone using Repeated Dose 28-day Oral Toxicity Study in Rats

Kenji TAKANOBU, Tetsuya TAKEUCHI, Hirokazu OKUDA, Nobuya IMATANAKA, Sh ...

Session ID: P-175
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4175.0

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Effects of gestational and lactational low-dose exposure to bisphenol A on rat offspring.

Kenichi Kobayashi, Katsumi Ohtani, Hisayo Kubota, Muneyuki Miyagawa

Session ID: P-176
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4176.0

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Effects of Methoxychlor and Ethynyl Estradiol on the Expression of Wnt7a and Indian Hedgehog Genes in the Uterus of Immature Female Rats

Seiichi KATAYAMA, Kazunori NARUMI, Koji ASHIZAWA, Kenji NAGAI, Hiroshi ...

Session ID: P-177
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4177.0

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Method Validation of Dopamine, Serotonin and the Two Dopamine Metabolites, DOPAC and HVA in Mouse Striatum Using LC-MS/MS Detection

Mark Nemec, Larry Eden, Shelly Hollar, Phil Stetson, Melissa Beck

Session ID: P-178
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4178.0

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Evaluation of neutrophilic airway inflammation in mice treated with toll-like receptor (TLR) ligands using a rapid cytometric method

Takashi Sakata, Yoji Nagira, Yuya Ezaki, Yu Kajiwara, Takeshi Murata, ...

Session ID: P-179
Published: 2009
Released on J-STAGE: July 17, 2009

DOIhttps://doi.org/10.14869/toxp.36.0.4179.0

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