Annual Meeting of the Japanese Society of Toxicology

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Poster presentations

Down-regulation of Cyp3a11 expression in the liver of mice fed cholesterol-free diet.

Kouichi Yoshinari, Shin-ichi Inoue, Mika Sugawara, Yasushi Yamazoe

Session ID: P-141
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20141.0

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Investigation of adducts formation via reactive acylglucronides using dansylated Lys-Phe as a trapping agent

Masahito Ito, Yukiko Eifuku, Kouji Takekawa, Akio Sugiyama

Session ID: P-142
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20142.0

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Effect of human serum albumin on the electrophilic reactivity of acyl glucuronides

Tadao Yoshioka, Akiko Baba

Session ID: P-143
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20143.0

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Evaluation of human spheroid cultures for prediction of human metabolites

Takako Ohkura, Kunihiro Ohta, Takuya Nagao, Kumiko Kusumoto, Akiko Koe ...

Session ID: P-144
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20144.0

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Development of a prediction system for CYP1A2-mediated mutagenic activation/inactivation of chemicals

YOSHIYA YAMAMURA, KAZUMI ITO, KOUICHI YOSHINARI, YASUSHI YAMAZOE

Session ID: P-145
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20145.0

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Effect of dietary constituents on the gene expression of mouse liver

Kazumi SUGIHARA, Hanaka SAKO, Miyuki ARAI, Seigo SANOH, Shigeyuki KITA ...

Session ID: P-146
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20146.0

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Morphological characterization of endoneurial microvasculature of transected sciatic nerves in diabetic rats

Yuzo TANIGUCHI, Hironobu OONISHI, Saori YAMADA, Misako YAMANAKA, Hirok ...

Session ID: P-147
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20147.0

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Effects of female sex hormones against drug-induced liver injury

Yasuyuki TOYODA, Koichi TSUNEYAMA, Tatsuki FUKAMI, Miki NAKAJIMA, Tsuy ...

Session ID: P-148
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20148.0

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IL-4 mediated methimazole-induced liver injury in mice

Masanori KOBAYASHI, Satonori HIGUCHI, Tatsuki FUKAMI, Miki NAKAJIMA, T ...

Session ID: P-149
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20149.0

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Molecular mechanism of sevretory pathway for oral sulfonylurea glibenclamide: relation to hepatotocitiy

Naohiko Anzai, Promsuk Jutabha, Daisaku Miura, Seiji Ueno, Toru Kimura ...

Session ID: P-150
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20150.0

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Gene expression profiling to acquire data sets correlated with repeated dose 28-day oral toxicity studies in rodents

Jun-ichi Imai, Satoko Kato, Mika Kawamura, Shinya Watanabe

Session ID: P-151
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20151.0

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Involvement of COPII trafficking system in reduction of adriamycin toxicity

Chisato FUKAZAWA, Satoko HAREYAMA, Ken-ichiro HIROSE, Tsutomu TAKAHASH ...

Session ID: P-152
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20152.0

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Quantitative evaluation of bile acid dependent drug-induced liver injury in Sandwich cultured rat hepatocytes

Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie

Session ID: P-153
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20153.0

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Problems and proposals for in silico (computer-assisted) toxicity prediction

Kohtaro Yuta

Session ID: P-154
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20154.0

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Risk Assesment in the 21st Century: Realizing the Future of Risk Assessment

Ayako Takei, Alan Boobis, Michelle Embry, Tim Pastoor

Session ID: P-155
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20155.0

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Changes in TAT, PAI-1, and PIC in a coaugulation and fibrinolytic abnormality model induced by LPS and thrombin in cynomolgus monkeys

Hirofumi Minomo, Yasunori Taniguchi, Kayoko Wada, Shiho Tsutsumi, Taka ...

Session ID: P-156
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20156.0

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Basic study for Blood coagulation systems test in cynomolgus monkeys

Yoshitaka HIRASAWA, Masaaki KURATA, Michiyo NAKAJIMA, Kengo SAKAMOTO, ...

Session ID: P-157
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20157.0

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An investigation of the effects on kinetics by changes of dispersant components.

Masaharu Fujita, Miyuki Akimoto, Naohisa Umeya, Atsuko Yuasa, Takanori ...

Session ID: P-158
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20158.0

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Investigation of the usability of spheroid culture system using human hepatocytes for hepatotoxicity evaluation (1)

Daichi Nagai, Makiko Otsuji, Motoharu Kakiki, Jun Katagi, Norihito Mat ...

Session ID: P-159
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20159.0

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Investigation of the usability of spheroid culture system using human hepatocytes for hepatotoxicity evaluation (2)

Hisakazu Iwai, Yukiko Inoue, Motoharu Kakiki, Makiko Otsuji, Sho Tanak ...

Session ID: P-160
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20160.0

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Detection of drug-induced liver injury by reactive acylglucuronides or mitochondrial DNA polymerase gammma inhibitors using human hepatocyte spheroid cultures.

Jun Katagi, Norihito Matsumoto, Shinya Kaneda, Yuichiro Yoshioka, Taku ...

Session ID: P-161
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20161.0

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Chemotherapeutics-induced nausea and emesis is predictable by delayed gastric emptying in rats

Kentaro Ando, Kan Takagi, Hirokazu Tsubone

Session ID: P-162
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20162.0

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Evaluation of high-throughput screening in vitro micronucleus test using fluorescence-based cell imaging system.

Aya Shibai, Chihaya Kakinuma, Takanori Hioki, Toshihiko Kasahara

Session ID: P-163
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20163.0

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In vivo phototoxicity evaluation using albino and pigmented rats

Ryota KAWAI, Keiko MURAMATSU, Makoto SHIRAI, Makoto AKAI, Tadashi FURU ...

Session ID: P-164
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20164.0

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Back Ground Data for Carcinogenicity Study in Wistar Hannover (RccHan^TM:WIST) Rats

Toshiya OKAMURA, Takashi KAMATA, Kazuhisa HATAYAMA, Osamu KUSUOKA, Tat ...

Session ID: P-165
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20165.0

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Detection of the food contaminants with the emetic response of Suncus murinus and the electrophysiological technique in rats

Kentaro Tanaka, Akira Uchida, Sayuri Yamada, Yoshie Hiwata, Osamu Taji ...

Session ID: P-166
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20166.0

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Comparison of postnatal development parameters including behavioral assessments between two rat strains of SD and Wster Hannover

Tetsuya Fukuta, Chiyomi Kojima, Ikuyo Shiraisi, Hiromi Katsuyama, Toru ...

Session ID: P-167
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20167.0

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Research on the implementation of non-clinical toxicity study in juvenile animals in drugs for pediatric indications approved in Japan

Yoshinobu AOKI, Kazuhiro SHIMOMURA, Kiyoshi MATSUMOTO, Mutsumi SUZUKI, ...

Session ID: P-168
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20168.0

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Comparison of FDA guidance (2006) and EMEA guidance (2008) for non-clinical toxicity study in juvenile animals of drugs for pediatric indications

Mutsumi Suzuki, Kazuhiro Shimomura, Kiyoshi Matsumoto, Yoshinobu Aoki, ...

Session ID: P-169
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20169.0

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Evaluation of Chemical Phototoxicity by Detecting Phosphorylated Histone H2AX

Yuko Ibuki, Tatsushi Toyooka

Session ID: P-170
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20170.0

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Continuous carcinogenic susceptibility monitoring of CB6F1 TG rasH2 mice

KOJI URANO, KAZUHIKO MACHIDA, EIKO NISHINAKA, KAZUAKI ITO, MASASHI TOM ...

Session ID: P-171
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20171.0

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Investigation of toxicity model of anticancer drug in rat -Evaluation of toxicity on hemopoietic organs and digestive organs-

Hiro Fujisawa, Takaya Momiyama, Naruyuki Michitani, Yoshitaka Hatakeya ...

Session ID: P-172
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20172.0

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Effects of feed components on the lipid metabolism in rats

Hiromi Nozaki, Masao Matsuura, Masao Kiguchi, Masao Horimoto, Mariko H ...

Session ID: P-173
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20173.0

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Blood parameter measurements in cynomolgus monkeys from cambodia

Hiroyuki YAMASHITA, Kensuke MIZUYOSHI, Hiroshi UCHINO, Takeshi FUKUDA, ...

Session ID: P-174
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20174.0

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Hepatic cytochrome P450 gene expression analysis for cynomolgus monkeys in Cambodia

Ryota Ise, Tsuyoshi Yoshikawa, Hiroyuki Yamashita, Yasuhiro Uno

Session ID: P-175
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20175.0

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Novel gene markers of immunosuppressive chemicals in mouse lymph node assay

Kieyu Oshida, Akihisa Maeda, Mika Kitsukawa, Sachiko Suga, Shunsuke Iw ...

Session ID: P-176
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20176.0

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Evaluation of phospholipidosis-inducing potential of drugs from oral single-dose rat liver gene expression profiling

Takahiro Yudate, Toshihiro Kai, Yohsuke Minowa, Mikio Aoki, Toru Yamad ...

Session ID: P-177
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20177.0

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Application of open source software for developing toxicogenomics analytical workflow

NAOKI KIYOSAWA, TAKEHIRO HIRAI, KOICHI TAZAKI, MASATOSHI NISHIMURA, TA ...

Session ID: P-178
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20178.0

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Metabolomic approach to investigating the mechanism and biomarkers of bleomycine-induced pulmonary injury

Kiyoko Bando, Takeshi Kunimatsu, Juki Kimura, Hitoshi Funabashi, Takak ...

Session ID: P-179
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20179.0

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Toxicogenomic approach for identifying marker genes of liver toxicity in rat whole blood

Noriyuki Nakatsu, Hiroshi Yamada, Tetsuro Urushidani, Yasuo Ohno

Session ID: P-180
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20180.0

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Predictive value of QSAR and toxicogenomic models for drug-induced hepatotoxicity

Takeki Uehara, Yen Low, Yohsuke Minowa, Alexander Sedykh, Eugene Murat ...

Session ID: P-181
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20181.0

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Comparison research on hepatotoxicity biomarkers in acetaminophen-treated rats

Keiichi Minami, Chiaki Uenishi, Yoshinobu Igarashi, Junichi Kino, Masa ...

Session ID: P-182
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20182.0

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Exploratory research of plasma microRNAs as potential biomarkers for liver injury

Takehiro Kiko, Naoki Toritsuka, Etsuko Ota, Yuko Hasegawa, Kyoko Agemu ...

Session ID: P-183
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20183.0

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Online Analysis System of the Percellome Project

Ken-ichi Aisaki, Katsuhide Igarashi, Kentaro Tanemura, Yukuto Yasuhiko ...

Session ID: P-184
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20184.0

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Identification of genomic biomarkers and construction classifier for assessment of potential cytotoxic hepatocarcinogenicity of chemicals in rats using a large-scale toxicogenomics database

Yuji Morikawa, Takeki Uehara, Yohsuke Minowa, Noriyuki Nakatsu, Yasush ...

Session ID: P-185
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20185.0

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Assessment of novel eye irritation test using the reconstructed human corneal tissue LabCyte CORNEA-MODEL

masakazu katoh, Noriyuki Uemura, Akemi Usui, Ken-ichiro Hata

Session ID: P-186
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20186.0

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Evaluation of detection method of low irritating substances by in vitro skin irritation test using the human 3-D epidermal model

Mika Watanabe, Miwako Kobayashi, Hiroko Okutomi, Tomoko Shindo, Fumiak ...

Session ID: P-187
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20187.0

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Evaluation of human Cell Line Activation Test (h-CLAT) to detect the skin sensitization potential of chemicals

Keiko Fujita, Mika Watanabe, Miwako Kobayashi, Hiroko Okutomi, Tomoko ...

Session ID: P-188
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20188.0

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Evaluation of skin irritation of oil using monolayer culture system

Noriyasu Imai, Yuko Okamoto

Session ID: P-189
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20189.0

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historical control data in rasH2 mice used in short-term (26-Week) carcinogenicity model

yasunori masubuchi, yuko yamaguchi, yuichi kuroiwa, kazushi okazaki, k ...

Session ID: P-190
Published: 2011
Released on J-STAGE: August 11, 2011

DOIhttps://doi.org/10.14869/toxp.38.0.20190.0

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