YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
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67件中1~20件の論文を表示しています
  • 143 巻 (2023) 6 号 p. 511-531
    植物由来の血圧下降成分研究から天平時代の毒と『竹取物語』との関係の謎に迫るまで もっと読む
    編集者のコメント

    The author, a natural product chemist and prolific author, has conducted significant phytochemical research and the discovery of new antibiotics. His classification of naturally occurring alkaloids into 16 categories according to their biosynthetic pathways is a highly significant achievement. He has written many books related to poisons and medicines, and disclosed the fundamental relationship between "Taketori-Monogatari" and "Shosoin-Drugs (poisons)" through extensive literature research. Cumulatively, these are extremely profound research and scholarly contributions to science and society.

  • 143 巻 (2023) 5 号 p. 449-457
    地域住民に対する「くすり実験教室」による医薬品の適正使用の推進 もっと読む
    編集者のコメント

    There are many lectures for the regional community residents as with the aim of promoting appreciate use of medications. The authors’ activity is characterized as consisting of combined lectures and practices by pharmacists. This activity indicated that it improved the basic medicine-related knowledge of the regional community residents among a wide range of age groups. The authors’ activity leads to the development of regional community activity, by the coming together of the regional community residents of various age.

  • 143 巻 (2023) 4 号 p. 323-336
    窒素原子を含む結合活性化学種の発見 もっと読む
    編集者のコメント

    Chemical bonds are drawn as lines connecting atoms to atoms. Even chemical bonds represented by uniform lines have various properties depending on the arrangement of the surrounding atoms. When the lines are formed by nitrogen atoms, several characteristic chemical bonds were observed. The nature of these characteristic chemical bonds depends on the overall structure of the molecule. This review also explains how new chemical bonds have led to the creation of new functions, such as biological activity.

  • 143 巻 (2023) 3 号 p. 281-295
    小児在宅医療における薬剤師の実践モデルの構築の試み もっと読む
    編集者のコメント

    This study developed a practice model of pharmacists in pediatric homecare medicine by the data analyzed using the M-GTA. This analysis generated 8 categories and 21 concepts, including the two concepts of “optimization of prescription and device selection to enable the hospital-to-home transition” and “optimization of prescription and device selection for ensuring patient safety” form the core of clinical decision making in the pharmacotherapy management process. These results could be helpful in the education of pharmacists in pediatric homecare medicine.

  • 143 巻 (2023) 2 号 p. 139-152
    医療用医薬品の品質問題と安定供給 もっと読む
    編集者のコメント

    Multiple good manufacturing practice (GMP) incompliance and inappropriate quality cases of generic pharmaceuticals surfaced from 2020 led to a serious and long-term shortage of the products at medical institutions in Japan. This review overviewed the causes of drug shortages and introduced measures taken by marketing/manufacturing authorization holders (MAH), industry groups, and governments to improve manufacturing management. Inadequate formulation and process design at the time of development as a possible root cause was also discussed.

  • 143 巻 (2023) 1 号 p. 65-75
    Sandhoff病の新規治療法を目指した病態解析 もっと読む
    編集者のコメント

    Sandhoff disease (SD) is a glycosphingolipid storage disease resulting from a genetic mutation in HEXB and associated deficiency in β-hexosaminidase activity. To examine abnormal neuronal lineage differentiation and development during the asymptomatic phase of SD, authors used iPS cells derived from Hexb-knockout mice (SD-iPSCs). Differentiation ability along the time axis appears to be altered in SD-iPSCs, in which neural stem cells acquire late developmental properties at an early stage. Their findings provide new insights into the complex pathogenesis of SD.

  • 142 巻 (2022) 12 号 p. 1371-1377
    緑茶の効能:気道感染症に対する臨床的エビデンス もっと読む
    編集者のコメント

    Green tea components, such as catechins are reported to have anti- viral/bacterial and anti-inflammatory effects in experimental studies. This review demonstrated the clinical significance of green tea focusing on the respiratory tract infections based on their clinical studies. Consuming or gargling green tea or its components significantly aided in the prevention of influenza. Catechin inhalation also decreased the bacterial load of methicillin-resistant Staphylococcus aureus. Although the clinical evidence remains limited, further studies are expected to clarify the clinical efficacy.

  • 142 巻 (2022) 11 号 p. 1255-1265
    医薬品製剤のトレーサビリティを担保するmicrotaggant技術:偽造医薬品対策と流通・服薬管理への可能性 もっと読む
    編集者のコメント

    The need for ensuring the traceability of pharmaceutical products from shipment to patient distribution is growing with the spread of falsified medicine and poor medication adherence. The microtaggant technologies that can encode individual numbers on pharmaceutical products has gained much attention to solve these problems. The author well organized the advantages and disadvantages of each encoding method of the microtaggants. This review is useful to understand the emerging traceability system.

  • 142 巻 (2022) 10 号 p. 1091-1101
    Gタンパク質共役型受容体を介したバイアス型シグナリング もっと読む
    編集者のコメント

    Biased agonists of GPCRs are agonists that selectively induce G protein- or β-arrestin-mediated responses. Biased agonists have become an important concept in drug discovery, as they are thought to result in drugs with fewer side effects. It should be noted, however, that the actions of G protein biased agonists can also be explained by the effects of partial agonists. In many cases, biased agonists bind to and exert their effects at different sites than endogenous agonists.

  • 142 巻 (2022) 9 号 p. 977-991
    植物由来生理活性物質の探索と作用機構の解析 もっと読む
    編集者のコメント

    Bioactive compounds from plant (phytochemicals) play an important role as seed compounds for prevention and treatment of many diseases. Recently, the author isolated a novel topoisomerase II inhibitor named erypoegin K, an isoflavone from Erythrina poeppigiana, which showed enantio-selective potent apoptosis-inducing activity towards various types of cancer cells. This review mainly describes studies on erypoegin K. It also includes other phytochemicals with apoptosis-inducing and anti-inflammatory activities. This review is useful for researchers developing new anticancer and anti-inflammatory drugs.  

  • 142 巻 (2022) 8 号 p. 775-795
    生体内ビタミンE輸送の決定因子α-TTPの生理機能と先天性欠損症─日本薬学会賞受賞対象研究の一部として─ もっと読む
    編集者のコメント

    Vitamin E (α-tocopherol) is the most important lipid-soluble antioxidant in humans. The author identified a soluble protein that specifically binds α-tocopherol and named it α-tocopherol transfer protein (α-TTP). He found that α-TTP is a major determinant of vitamin E levels in the body and that its mutation causes severe vitamin E deficiency. α-TTP catalyzes intracellular vectorial transport of vitamin E by exchange with phosphatidylinositol phosphates (PIPs), and this mechanism may be applicable to other intracellular lipid transfer proteins.

  • 142 巻 (2022) 7 号 p. 755-760
    Performance Status不良群におけるナルデメジンの有効性の検証 もっと読む
    編集者のコメント

    Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation (OIC). However, patients in phase III trials are limited to those with good performance status (PS). This study aimed to evaluate Nal efficacy in patients with poor PS. In conclusion, Nal showed similar effectiveness in patients with poor PS as that in those with good PS. Authors findings could be helpful in the treatment of patients with OIC.

  • 142 巻 (2022) 6 号 p. 629-639
    天然薬物の有効成分 ─A Mixture Can Do More─ もっと読む
    編集者のコメント

    One of the important characteristics of natural medicines, including crude drugs and Kampo prescriptions, is that they contain many constituents, and their therapeutic effects result from the total effects of the constituents. The author reviewed various synergistic effects and interactions among the constituents of natural medicines experienced in his researches. This review will provide an opportunity to have a glimpse into the scientific basis of the effectiveness of natural medicines as multicomponent medicines.

  • 142 巻 (2022) 5 号 p. 439-446
    エピジェネティック制御を利用した糸状菌未利用遺伝子の活用と多様な天然物の創出 もっと読む
    編集者のコメント

    Discovery of natural products that possess novel chemical structures and pharmaceutical activities increases opportunities of drug development. In this post genomic era, it is cleared that fungi have a huge number of silent biosynthetic gene clusters and they are recognized as an attractive source for natural product discovery. The author developed methods to activate fungal silent biosynthetic gene clusters by using epigenetic modifiers and plant hormones and demonstrated their advantage to get a variety of new natural products.

  • 編集者のコメント

    There are still many diseases that have no therapeutic approach even today. Against this background, we have duty to think the future of the field of pharmacy. This paper describes the importance of sharing awareness of problems among different specialists such scientist and pharmacist. Furthermore, this paper also introduced the result of the symposium which consist of enzyme engineering, total synthesis and medicinal chemistry in the 141st annual meeting of the Pharmaceutical Society of Japan.

  • 142 巻 (2022) 3 号 p. 279-287
    繊維製品に含まれる防炎加工剤のビス(2,3-ジブロモプロピル)ホスフェイト及びトリス(2,3-ジブロモプロピル)ホスフェイトのGC-MS分析法 もっと読む
    編集者のコメント

    This research paper improves the TDBPP and BDBPP analysis methods of organic phosphorus flame retardants regulated by the Act on the Control of Household Products Containing Harmful Substances Japan. The authors proposed a GC-MS analysis method instead of the GC-FPD method. The new method is performed safely without using harmful reagents in the pretreatment. Furthermore, the high-sensitive analysis is realized by surrogate correction.  

  • 142 巻 (2022) 2 号 p. 165-179
    医薬品に適した生物活性フラーレン誘導体の創製 もっと読む
    編集者のコメント

    The author has an interest in unique chemical and physical properties of fullerene (C60) and fullerene derivatives, and has studied bio-active fullerene derivatives to develop novel lead compounds for drug discovery. He showed that anionic fullerene derivatives possess anti-oxidant activities, di-cationic fullerene derivatives exhibited antiproliferative activities against various cancer cell lines including drug-resistant cells, and proline-type fullerene derivatives showed anti-virus activities. The process of the studies is also written in this report.

  • 142 巻 (2022) 1 号 p. 65-74
    X線回折測定による医療用経皮吸収型製剤中の薬物結晶の検出と解析 もっと読む
    編集者のコメント

    The presence or absence of drug crystals in a matrix-type transdermal patch is generally confirmed by visual or optical observation of the exposed adhesive surface. This method consumes one patch per observation. The present study investigated the feasibility of crystal detection in a patch, enclosed in an unopened outer bag, by laboratory X-ray diffraction. The results showed that a laboratory-level high-resolution X-ray diffractometer can be used to detect unintentionally crystallized spots, and examine the crystalline state including polymorphism.

  • 141 巻 (2021) 12 号 p. 1305-1306
    老化と眼疾患─いつまでも健康な視機能を─ もっと読む
    編集者のコメント

    Due to aging society of Japan, ophthalmic research is becoming more importance in not only doctor and nurse but pharmacist. This symposium (review) shows the state of the art in “Age-related changes in eye function and preventive ways”, and update ophthalmic studies including senescence, antiaging, immune privilege and drug delivery system. Many members will be interested in the ophthalmic research field when they read this review, and the information will help to improve the “Quality of Vision” in aging society.

  • 141 巻 (2021) 11 号 p. 1267-1274
    X線結晶構造解析により明らかとなったPPARαとリガンドの結合様式 もっと読む
    編集者のコメント

    Three subtypes of peroxisome proliferator-activated receptors (PPARα, PPARγ, and PPARβ/δ) are attracting much attention as molecular targets of drugs to treat various metabolic diseases including dyslipidemia, type 2 diabetes, and non-alcoholic fatty liver disease; however, the structural information regarding their ligand binding pockets has been lacking, especially in PPARα. Kamata and Ishii give an overview of their recent success in obtaining 34 novel PPARα-ligand structures that supplement 21 previously PDB-deposited structures using their sophisticated crystallization techniques. 

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