Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
  • 141 巻 (2021) 5 号 p. 761-769
    Effects of Fibrates on Risk of Development of Diabetic Retinopathy in Japanese Working Age Patients with Type 2 Diabetes and Dyslipidemia: a Retrospective Cohort Study もっと読む

    This study investigated the effects of fenofibrate and bezafibrate on risk of diabetic retinopathy (DR) in Japanese working age patients with type 2 diabetes and dyslipidemia using electronic medical records. Although these fibrates did not affect development of DR, poor control of hemoglobin A1c (HbA1c) and low-density lipoprotein cholesterol (LDL-C) within the follow-up period increased the risk of DR. Thus, controlling HbA1c and LDL-C levels under coexistence type 2 diabetes and dyslipidemia is more important than the selection of fibrate.

  • 141 巻 (2021) 4 号 p. 447-462
    血液脳関門研究の新規手法の開発と輸送機能解明への応用 もっと読む

    The author introduced three methods to characterize the blood-brain barrier (BBB) transport function. It was shown that the BBB plays an important role in protecting the brain by transporting small molecules such as neurotransmitters, uremic toxins and xenobiotics together with proteins. Significant species differences were shown in the expression amounts of various BBB transporter proteins. Moreover, in vivo BBB efflux transport activity was predicted from in vitro study and transporter protein concentration.

  • 141 巻 (2021) 3 号 p. 403-413
    Evaluation of the Usefulness of Postoperative Analgesic Solution Preparation by Pharmacists in the Surgical Department もっと読む

    The authors report on pharmacists’ work that is unique to surgical departments. Pharmacists prepare drug solutions utilizing anesthesia recording systems, which they were involved in developing. Anesthesiologists request pharmacists to prepare drug solutions after estimating the degree of postoperative pain in the surgical field during surgery. Pharmacists then prepare specific solutions after consultation and discussion with anesthesiologists. In this study, the authors investigated the evaluation of pharmacists’ practices by anesthesiologists and found that pharmacists received favorable evaluations.

  • 141 巻 (2021) 2 号 p. 245-254
    膀胱運動に対するジスチグミンの長時間持続性増強効果の作用機序について もっと読む

    Distigmine is a cholinesterase inhibitor, which is used in Japan for the treatment for underactive bladder. Although the effectiveness of distigmine for underactive bladder treatment has been confirmed by many clinical reports, the pharmacological effects of distigmine on urinary bladder (UB) motility have not been well studied. In this review, the authors discuss the long-lasting potentiating effect of distigmine on guinea pig UB motility and the mechanism of these effects in guinea pig UB smooth muscle and recombinant human acetylcholinesterase.

  • 141 巻 (2021) 1 号 p. 111-124
    光安全性評価の現状と課題 もっと読む

    In this review, the authors first discuss the mechanisms of phototoxicity and how they can be evaluated. They then discuss the state of the art and challenges now faced in photosafety evaluation of pharmaceuticals and cosmetics. Additionally, they describe the latest developments in OECD test guidelines for assessing photosafety, including revisions to the 3T3 NRU phototoxicity test (TG 432) and the newly adopted ROS assay (TG 495).

  • 140 巻 (2020) 12 号 p. 1441-1454
    Rubric Assessment for Pharmacotherapy in Spiral Curriculum: Development and Usefulness Evaluation もっと読む

    The authors formulated a “Rubric assessment for pharmacotherapy” to continuously assess students’ ability to perform pharmacotherapy and provide patients with proper pharmacotherapy during student clinical rotations, and evaluated its usefulness. The rubric consists of three domains with 31 subdomains. Students were able to continuously self-assess their performance using the rubric, while continuously improving their achievement level. The rubric assessments may be useful for students to assess and improve their ability to practice pharmacotherapy.

  • 140 巻 (2020) 11 号 p. 1373-1380
    急性期脳梗塞患者におけるアルガトロバン投与中の症状悪化と投与方法の関連性についての検討 もっと読む

    The authors investigated the connection between differences in argatroban administration and worsening of symptoms after day 3 in ischemic stroke patients. Worsening of symptoms was not related to either intravenous or continuous infusion group. Bleeding was also not associated with either group. They suggest that the differences in the mode of argatroban administration were not related to the worsening of symptoms in ischemic stroke patients. They also found that safety was equivalent regardless of the administration route.

  • 140 巻 (2020) 10 号 p. 1269-1274
    The Effect of Increased Free Concentrations of Warfarin Due to Protein-binding Substitution in a Combination of Tolvaptan on the PT-INR もっと読む

    The authors investigated the drug–drug interactions between warfarin and tolvaptan by measuring drug blood concentrations in clinical patients and conducting in vitro albumin-binding experiments. They indicated that tolvaptan causes the free warfarin concentration to increase within 2 weeks of starting the combined treatment and the mechanism was albumin-binding substitution. This study shows that investigating and demonstrating various phenomena from the bedside enable pharmacists to provide better pharmaceutical care for patients.

  • 140 巻 (2020) 9 号 p. 1141-1150
    新規変形性関節症治療薬SI-613の膝関節における残存性評価 もっと読む

    The authors have reported that diclofenac etalhyaluronate (SI-613) exerted a long-lasting analgesic effect in experimental arthritis models. In this study, they evaluated the properties of residual SI-613 in the knee joint. The results suggested that intra-articularly administered SI-613 remained for a longer time in the joint as hyaluronic acid (HA) linked with diclofenac than intra-articularly administered HA. Therefore, SI-613 was considered to prolong the pharmacological effects of both HA and diclofenac by remaining in the joint as HA linked with diclofenac.

  • 140 巻 (2020) 8 号 p. 1025-1033
    Need for Prescription Suggestions for Long-term Inpatients in the Psychiatric Ward もっと読む

    The authors evaluated the effect of prescription suggestions by pharmacists to show the need for ward pharmacists’ services beyond 8 weeks for inpatients in the psychiatric ward. The pharmacists supported pharmacotherapy without exacerbating patient outcomes, decreased in benzodiazepine doses, and reduced healthcare expenditures were obtained for inpatients > 8 weeks of admission. This study showed that ward pharmacists’ services were necessary not only for the inpatients hospitalized for < 9 weeks, but also for those hospitalized for > 8 weeks.

  • 140 巻 (2020) 7 号 p. 923-928
    Liver Injury Risk Factors in Amyotrophic Lateral Sclerosis Patients Treated with Riluzole もっと読む

    Riluzole is a drug used to manage amyotrophic lateral sclerosis (ALS). Previous reports indicate a high incidence of liver injury in patients taking riluzole. Therefore, this study aimed to determine the risk factors for liver injury among patients who were prescribed riluzole from 1999 to 2015. As a result, concurrent use of CYP1A2 inhibitors, and history of smoking are independent risk factors associated with the development of liver injury in ALS patients who are prescribed riluzole.

  • 140 巻 (2020) 6 号 p. 789-798
    Evaluation of Hygiene in Dry Powder Steroid Drug Inhalers Used by Elderly Asthma Patients もっと読む

    The author hypothesized that an investigation of inhaler hygiene in relation to inhaler cleaning practices might help lower the risk of infection by determining the prevalence of improper cleaning methods in elderly asthma patients. This study showed that the hygiene of steroid drug inhalers used by those who did not perform any cleaning action after inhalation was poor, and suggested that a guidance on how to clean the inhaler would be important for the infection control.

  • 140 巻 (2020) 5 号 p. 701-710
    The Effect of Patient Age on Anticholinergic Use in the Elderly Japanese Population —Differences between Four Anticholinergic Scales もっと読む

    This study investigated attribution of each anticholinergic (AC) drug type to total AC burden in large elderly data in 2015-2016 using Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Drug Scale (ADS), Anticholinergic Risk Scale (ARS), and Beers criteria. AC use and burden increased with age with ACB and ADS but decreased with ARS and Beers criteria. Antihypertensives were the most attributable AC in ACB and ADS while antihistamines attributed the most in ARS.

  • 140 巻 (2020) 4 号 p. 577-584
    中心静脈栄養用輸液に混注されたインスリンの含量変化に関する検討 もっと読む

    The prevalence of home parenteral nutrition (HPN) continues to increase. Elneopa NF No. 1 and No. 2 infusions have been used for HPN, with insulin injected into the bags for patients with hyperglycemia. In this study, the authors studied the stability of insulin in the bags. It was revealed that the concentration of insulin injected into the bags decreases, especially in No. 2 bags. In addition, decreases in insulin levels were observed as the solutions passed through infusion sets.

  • 140 巻 (2020) 3 号 p. 435-441
    疎水化ヒドロキシプロピルメチルセルロースを用いたリポソームの架橋とレオロジー特性 もっと読む

    The liposome suspension and the hydrophobically-modified hydroxypropylmethylcellulose (HM-HPMC) aqueous solution each had low viscosities, but the viscosity increased rapidly when they were mixed. This is thought to be due to the formation of a 3D network structure caused by the hydrophobic group of HM-HPMC penetrating into the liposomal membrane, crosslinking the liposomes together. The viscosity of the liposome/HM-HPMC mixed solution decreased rapidly when a shear was applied, but immediately returned to the original gel state when the shear was removed.

  • 140 巻 (2020) 2 号 p. 301-312
    薬学生を対象としたEBM教育におけるチーム基盤型学習の導入とその評価 もっと読む

    Much less education has been done on literature evaluation in the Japanese education of pharmaceutical sciences. The authors adopted team-based learning (TBL) to educate undergraduate students on the practical evaluation of literature and the understanding of evidence-based medicine (EBM) concepts. The mean scores on the post-test significantly improved from 4.34 to 6.42 out of 10 total points. These results suggested that TBL was effective in EBM education for providing knowledge of literature evaluation and the understanding of fundamental concepts.

  • 140 巻 (2020) 1 号 p. 63-79
    骨吸収抑制薬bisphosphonatesによる顎骨壊死の機序・予防・治療に関する基礎研究 もっと読む

    In patients being treated with bisphosphonates (anti-bone-resorptive drugs), bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious concern. The authors demonstrate that nitrogen-containing bisphosphonates (N-BPs) are transported into soft-tissue cells via phosphate transporters and therein exhibit cytotoxicity, while non-nitrogen-containing bisphosphonates (non-N-BPs) inhibit this transportation. Based on results from animal and clinical studies, they propose that the non-N-BPs etidronate and clodronate may be useful for preventing and/or treating BRONJ. They also demonstrate that N-BP-induced toxicity is augmented by infection.

  • 139 巻 (2019) 12 号 p. 1601-1608
    Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration もっと読む

    Paclitaxel (PTX)-associated acute pain syndrome (P-APS) is characterized by disabling but transient arthralgia and myalgia in up to 80% of patients administered with PTX. In this study, it was revealed that clinical condition that needs non-steroidal anti-inflammatory drugs (NSAIDs) and previously administered NSAIDs prior to PTX injection do not affect the incidence, severity, and duration of P-APS. These results will help in educating patients about their medications and will contribute to the management of P-APS.

  • 139 巻 (2019) 11 号 p. 1449-1456
    電子診療録へのスタンプ貼付によるベンゾジアゼピン受容体作動薬減薬の取り組みとその評価 もっと読む

    The authors on the liaison team have been applying digital labels with recommendations for the reduction of use and changes in the medication orders and prescriptions of BZDs on electronic medical records. This study showed that the medication orders for BZDs were reduced after the implementation of digital labels and that the reduction effect was maintained for a certain period of time, and suggest that the liaison team pharmacist-led approach can contribute to the proper use of BZDs.

  • 139 巻 (2019) 10 号 p. 1327-1332
    血清クレアチニン補正による腎機能評価が子宮頸がんシスプラチン+フルオロウラシル療法に与える影響 もっと読む

    Different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level determined by the enzyme method being lower than that by the Jaffe method. This study investigated whether assessment of renal function with or without Scr adjustment affects cisplatin-based chemotherapy in cervical cancer patients. The results suggest that evaluation of renal function using the adjusted Scr is important for an appropriate dose adjustment of cisplatin in clinical practice.