YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
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  • 138 巻 (2018) 9 号 p. 1217-1225
    Outcomes of Pharmacists' Involvement with Residents of Special Nursing Homes for the Elderly もっと読む
    編集者のコメント

    The current study aimed to examine the outcomes of pharmacists’ involvement in special nursing homes. We analyzed 58 cases involving regular visits by community pharmacists. Pharmaceutical consultation following medication use accounted for 60.3% of pharmacists’ involvement with residents. The outcomes of these consultations included improvements in prescription content; the identification and prevention of adverse drug events; improvement in ADL. The findings indicated that regular visits by pharmacists to facilities for elderly people and communicate with care professionals improved pharmacotherapy outcomes.

  • 138 巻 (2018) 8 号 p. 1103-1110
    Study of Child-resistant Packaging Technologies to Prevent Children from Accidental Ingestion of Drugs in Japan もっと読む
    編集者のコメント

    This study investigated pediatric characteristics such as literacy ability and finger function in Japanese subjects and examined the usefulness of child-resistant (CR) packaging technologies. The authors indicated that the CR packaging styles that rely on literacy, the ability to use tools, and the ability to perform complex operations are only applicable to children of a certain age. These results may help to adopt CR packaging for Japanese children, and may be reduce accidental drug ingestion by children in Japan.

  • 138 巻 (2018) 7 号 p. 963-971
    児童におけるノンアルコール飲料摂取が飲酒と喫煙に与える影響 もっと読む
    編集者のコメント

    Non-alcoholic beverages with < 0.00% alcohol are on sale for adults as substitutes for alcoholic beverages, but it is unclear whether they could be a risk factor in drinking and smoking in childhood/adolescence. The authors indicated that 21.9 % of pupils in elementary school have drunk non-alcoholic beverages related with family drinking, and that non-alcoholic beverage intake is related to drinking and smoking. They also will introduce drug abuse prevention education among childhood/adolescents based on this survey.

  • 138 巻 (2018) 6 号 p. 829-836
    セロトニンを介した母乳産生制御メカニズム もっと読む
    編集者のコメント

    Intrinsic 5-HT synthesized within the mammary epithelium has an important physiological role in milk volume homeostasis. When the mammary gland becomes filled with milk, 5-HT provides a negative feedback signal that suppresses further milk synthesis in the mammary epithelium. Our research, using MCF-12A cells, shows that the expression of b-casein, a differentiation marker, is suppressed via 5-HT-mediated inhibition of STAT5. Additionally, our results show that reduced b-casein expression in the cells is associated with 5-HT7 receptor and PTP1B activation.

  • 138 巻 (2018) 5 号 p. 591-598
    体内動態と細胞内動態を制御する革新的リポソームDDSの創製と薬物治療・核酸医薬への展開 もっと読む
    編集者のコメント

    The modification of polyethylene glycol (PEG), i.e. PEGylation is commonly used approach for increasing stability of drug delivery systems (DDSs), but results in loss of activity simultaneously. This article describes the trade-off relationship between activity and stability as PEG dilemma and strategies to overcome PEG dilemma. The authors developed a cleavable PEG lipid in response to tumor microenvironment, a pH-sensitive fusogenic peptide, and pH-sensitive cationic lipids in response to endosome/lysosome, which balanced activity and stability of DDSs and exerted therapeutic effect of nucleic acid cargos.

  • 138 巻 (2018) 4 号 p. 551-557
    ホルムアルデヒド及びアセトアルデヒドの定量分析におけるqNMRを用いたトレーサビリティの確保 もっと読む
    編集者のコメント

    The exposure to aldehydes via indoor air is a matter of concern. Since there are no certified reference materials for aldehyde derivatives, the quantified values are not sufficiently reliable. In this study, the authors showed the actual content and purity of commercially available aldehyde derivatives using 1H-qNMR. Because it is greatly important for the quality control of reagents to secure the accuracy of analytical data, the qNMR analysis works as a bridge of International System of Units traceability.

  • 138 巻 (2018) 3 号 p. 425-435
    外来がん化学療法における薬薬連携に関するアンケート調査
    ─保険薬局薬剤師,病院薬剤師が相互に求める業務の比較─
    もっと読む
    編集者のコメント

    Previous reports suggested that sharing outpatient information during chemotherapy is very important for managing pharmaceutical usage between community pharmacies and hospitals. We herein examined using a questionnaire survey whether pharmaceutical management for outpatient chemotherapy is desired by community and hospital pharmacists. In conclusion, as there may be differences in opinion between community and hospital pharmacists, mutual preliminary communication is important for successful outpatient chemotherapy.

  • 138 巻 (2018) 2 号 p. 221-228
    Modification of the Insulin Pen Assistive Device to Improve the Usability and Its Evaluation もっと読む
    編集者のコメント

    In this study, we prepared 4 assistive devices (A-D) for Insulin Pen to improve the “ease of holding” and “ease of pushing” and compared their usability with that of a device provided by the pharmaceutical company (S). Fifty-five healthy volunteers in their 20s performed the self-injection maneuver using all 5 assistive devices and ranked them regarding above 3 items. In all evaluation items, C was ranked first by the largest number of subjects. Moreover, the 4 assistive devices prepared in this study were rated to be equal to or higher than S.

  • 138 巻 (2018) 1 号 p. 91-96
    Sex Differences of the Inflammatory Mediator Level at the Time of Itch Onset in Patients with Chronic Venous Disease もっと読む
    編集者のコメント

    This study investigated the sex differences of the inflammatory mediator level at the time of itch onset in patients with chronic venous disease (CVD). CVD-associated itching was observed in both men and women. In this study, itching was related to increased tryptase in women and increased adrenocorticotropic hormone and β-endorphin in men. Our findings could be helpful in the treatment of patients with CVD.



  • 137 巻 (2017) 12 号 p. 1517-1531
    保険薬局を対象とした生活習慣病予防に関する遺伝子検査セミナーの実施と評価
    —薬局-大学間連携の必要性—
    もっと読む
    編集者のコメント

    The authors held a seminar for pharmacists about genetic testing for lifestyle-related disease genes, with the aim of contributing to the prevention of lifestyle-related diseases. The authors showed that collaboration between pharmacies and universities is important for developing future seminars for the general public. This is because some pharmacists do not wish to know the results of private genetic testing, and most believe that the support of universities is necessary for the genetic testing of customers.

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