Connectin, also called titin, a giant elastic protein of striated muscle (-3000kDa), mainly consists of fibronectin type III and immunoglobulin C2 globular domains, the β-sheets of which are largely parallel to the main axis of the molecule. One connectin molecule runs through the I band and binds onto the myosin filament up to the M line starting from the Z line. It positions the myosin filament at the center of a sarcomere. Connectin is also responsible for resting tension generation. Biodiversity of the connectin family exists in invertebrate muscle.
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