When anti-rat kidney serum obtained from rabbits by Heymann's method was administered intravenously (1.4ml/100g B. W.×1/3×3 days) to rats, the following syndrome was induced.
1) Strong proteinuria was produced immediately and continued for 30 days at a high level. Excretion of alkaline phosphatase (AP) and lactic dehydrogenase (LDH) in urine significantly increased, while Na⁺ excretion decreased.
2) In addition to the appearance of hypoproteinemia and decrease of AP activity in blood, hyperlipemia and the elevations of blood urea nitrogen, creatinine and LDH activity were observed at an early stage.
3) On the other hand, protein concentration and AP activity in whole kidney homogenate diminished, whereas a significant increase of glucose-6-phosphate dehydrogenase activity was recognized for 20 days while that of LDH activity was weakly.
4) Considerable retention of ascites and kidney hypertrophy were observed as serious at autopsy.

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In order to find out what influence the respiratory functional abnormality would have on urinary lactic acid, pyruvic acid and acetilation rate in lung tnberculosis, the author selected 52 cases of lung tuberculosis whose symptoms were relatively steady and without any complication, and with these cases as the subjects, pathological conditions of the lung, especially respiratory insufficiency as determined by percent vital capacity, and liver functional disorders were compared with lactic acid and pyruvic acid values in urine and acetilation rate.
Lactic acid was measured by the hydroquinone method while pyruvic acid by the dinitrophenyl hydrazine method. Acetilation rate was determined by using paraaminobenzoic acid, which was done by Bratton-Marschall's method.
Urinary lactic acid was found to be relatively increased only in those cases with lung cavitation, and among the other examinations, especially with the percent vital capacity, there could be recognized no significant relationship.
Urinary pyruvic acid was increased in those cases with lung cavitation as well as a mutual relationship with the length of disease. Furthermore, there was observed an aggravating tendency in the lowering of percent vital capacity.
As for the rate of acetilation, although there was no definite relationship between the severity of tuberculosis and the percent vital cadacity, all the cases showed a marked decrease in the percent vital capacity, especially so in the groups using PAS and SF. It was thus assumed that chemotherapy has a great influence aside from the pathological conditions of the lung.

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By adding various substrates such as glucose, lactate, pyruvate, aspartate, malate, and alanine to both acatalasemia patients and the normal, the fluctuation of the pyruvic acid contents accompanying the respiration of erythrocytes had been investigated, but no difference of the contents could be observed between the two groups. Thus it has now become clear that even in these patients the pyruvic acid in erythrocytes, in so far as the respiration of erythrocytes, takes hardly any acitve part in the disposal of H₂O₂supposedly to be liberated during respiration.

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In this report the influence of several glucocorticoids on fasting blood sugar level, urinary glucose excretion, body weight and glucose tolerance were studied in rats with experimental steroid diabetes.
Steroids used in this experiment were cortisone, prednisolone, dexamethasone, and betamethasone. The doses were 10 mg, 2.0 mg, 0.4 mg, and 0.4 mg, respectively.
The experimental period was two weeks. The rats were fed with high carbohyrate diet for 6 days the experiment began and then corticosteroids were administered.
The glucose tolerance was measured just before and on the last day of the experiment.
The results are summarized as folllows :
1) Fasting blood sugar level was highest in rats administered with prednisolone, and was followed by rats treated with cortisone, dexamethasone, betamethasone, respectively.
2) Urinary glucose excretion was most remarkable in rats administered with dexamethasone, and was followed by those given prednisolone, betamethasone, cortisone, respectively.
3). The rats treated with prednisolone showed the lowest glucose tolerance, and were followed by those given dexamethasone, cortisone and betamethasone in that order.
4) The decrease in body weight of rats treated with dexamethasone was most remarkale, and was followed in those treated with betamethasone, cortisone, prednisolone in lesser degrees, sespectively.
5) Parallel relationship between urinary glucose excretion and glucose tolerance was seen. However, inverse relationship was seen between rise of fasting blood sugar level and decrease of body weight.

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